2-Naphthyl phenyl ketone

Base Information

• Chemical Name: 2-Naphthyl phenyl ketone
• CAS No.: 644-13-3
• Molecular Formula: C17H12 O
• Molecular Weight: 232.282
• Hs Code.: 2914399090
• European Community (EC) Number: 211-410-6
• NSC Number: 5190
• UNII: RM48ZB8PA6
• DSSTox Substance ID: DTXSID50883522
• Nikkaji Number: J134.380G
• Wikidata: Q82862454
• ChEMBL ID: CHEMBL1712642
• Mol file: 644-13-3.mol

Synonyms:2-Naphthyl phenyl ketone;644-13-3;2-Benzoylnaphthalene;naphthalen-2-yl(phenyl)methanone;2-Benzonaphthone;Methanone, 2-naphthalenylphenyl-;2'-Benzonaphthone;Ketone, 2-naphthyl phenyl;beta-Benzoylnaphthalene;2-Naphthyl(phenyl)methanone;(naphthalen-2-yl)(phenyl)methanone;.beta.-Benzoylnaphthalene;MFCD00004106;RM48ZB8PA6;MLS002637798;NSC 5190;NSC-5190;EINECS 211-410-6;ss-Benzoylnaphthalene;2-Benzoyl-naphthalin;Phenyl 2-naphthyl ketone;UNII-RM48ZB8PA6;2-Naphthalenylphenylmethanone;.beta.-Naphthyl phenyl ketone;SCHEMBL124894;2-Naphthyl(phenyl)methanone #;CHEMBL1712642;DTXSID50883522;NSC5190;HMS3085M17;AKOS009159522;RS-1030;SB66853;SMR001547315;B0301;CS-0156554;FT-0613145;D88626;A834747;AG-205/01892005

Chemical Property of 2-Naphthyl phenyl ketone

Chemical Property:

• Appearance/Colour: white to pale yellow powder
• Melting Point: 76-82 °C
• Refractive Index: 1.5000 (estimate)
• Boiling Point: 216-216°C 7mm
• Flash Point: 216-216°C/7mm
• PSA: 17.07000
• Density: 1.0696 (rough estimate)
• LogP: 4.07080
• Storage Temp.: Store below +30°C.
• Solubility.: Soluble in hot methanol.
• XLogP3: 4.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 232.088815002
• Heavy Atom Count: 18
• Complexity: 290

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Naphthyl Phenyl Ketone >98.0%(GC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: N
• Statements: 36/37/38-51/53
• Safety Statements: 24/25-61

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(=O)C2=CC3=CC=CC=C3C=C2
• Uses: 2-Benzoylnaphthalene is used as pharmaceutical intermediate.

Technology Process of 2-Naphthyl phenyl ketone

There total 196 articles about 2-Naphthyl phenyl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

carbon monoxide (201230-82-2) + 2-naphthyldiazonium tetrafluoroborate (450-58-8) + phenylboronic acid (98-80-6) → 2-phenylnaphthalene (612-94-2) + C6H5COC10H7 (644-13-3)

Guidance literature:

With palladium diacetate; 1,3-bis[(2,6-diisopropyl)phenyl]imidazolinium chloride; In 1,4-dioxane; at 100 ℃; for 5h; under 760 Torr;

DOI:10.1016/S0040-4039(02)02186-X

Reference yield: 33.0%

2-(2,4-dihydro-1H-isochromen-1-yl)-1-phenylethanone (100008-34-2) → 2-phenylnaphthalene (612-94-2) + C6H5COC10H7 (644-13-3) + 3-phenyl-1,2-dihydronaphthalene (20669-52-7) + (2-naphthyl)phenylmethanol (35060-38-9)

Guidance literature:

With potassium tert-butylate; In benzene; at 50 - 60 ℃; for 2h; Yields of byproduct given;

Reference yield:

2-bromonaphthalene (580-13-2) → 2,2'-binaphthalene (612-78-2) + C6H5COC10H7 (644-13-3)

Guidance literature:

Multistep reaction. Yields of byproduct given;

DOI:10.1080/00397919808003074

upstream raw materials:

2-naphthalenecarbonitrile

phenyl(5,6,7,8-tetrahydronaphthalen-2-yl)methanone

naphthalene

benzoyl chloride

Downstream raw materials:

(2-naphthyl)phenylmethanol

1-phenyl-1-(2-naphthyl)-3-methylbutane-1,3-diol

1-phenyl-1-(2-naphthyl)-2-ethylpropane-1,3-diol

1-phenyl-1-(2-naphthyl)pentane-1,3-diol

Refernces

• 1、 Oh, Chang Ho,Kim, Ahyun,Park, Wooram,Park, Dai In,Kim, Nakjoong. "Synthesis of 2-acyl-3-arylnaphthalenes by dual catalysis of sodium tetrachloroaurate toward alkyne-propargylic acetates". . p. 2781 - 2784. Retrieved 2006.
• 2、 Bisz, Elwira,Chen, Hao,Dziuk, B?a?ej,Ejsmont, Krzysztof,Lalancette, Roger,Pyle, Daniel J.,Rahman, Md. Mahbubur,Szostak, Michal,Szostak, Roman,Wang, Qi. "Evaluation of Cyclic Amides as Activating Groups in N-C Bond Cross-Coupling: Discovery of N-Acyl-δ-valerolactams as Effective Twisted Amide Precursors for Cross-Coupling Reactions". . p. 10455 - 10466. Retrieved 2021/07/31.
• 3、 Yu, Tao,Guo, Mingqing,Wen, Simiaomiao,Zhao, Rongrong,Wang, Jinlong,Sun, Yanli,Liu, Qixing,Zhou, Haifeng. "Poly(ethylene glycol) dimethyl ether mediated oxidative scission of aromatic olefins to carbonyl compounds by molecular oxygen". . p. 13848 - 13852. Retrieved 2021/04/22.