2-chloro-n-naphthalen-1-yl-acetamide

Base Information

• Chemical Name: 2-chloro-n-naphthalen-1-yl-acetamide
• CAS No.: 832-89-3
• Molecular Formula: C12H10 Cl N O
• Molecular Weight: 219.671
• Mol file: 832-89-3.mol

Synonyms:Acetamide,2-chloro-N-1-naphthyl- (6CI,7CI,8CI); 2-Chloro-N-(1-naphthyl)acetamide;Chloroacetyl-1-naphthylamide; N-(1-Naphthalenyl)chloroacetamide; NSC 18826

Chemical Property of 2-chloro-n-naphthalen-1-yl-acetamide

Chemical Property:

• Vapor Pressure: 4.54E-08mmHg at 25°C
• Boiling Point: 443.7°C at 760 mmHg
• Flash Point: 222.1°C
• Density: 1.307g/cm³

Purity/Quality:

98%min ^*data from raw suppliers

2-chloro-N-(naphthalen-1-yl)acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-chloro-n-naphthalen-1-yl-acetamide

There total 3 articles about 2-chloro-n-naphthalen-1-yl-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.3%

1-amino-naphthalene (134-32-7) + chloroacetyl chloride (79-04-9) → 2-chloro-N-(1-naphthyl)acetamide (832-89-3)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 25 ℃;

DOI:10.1021/jm1011534

Reference yield: 92.0%

Chloroiodomethane (593-71-5) + 1-Naphthyl isocyanate (86-84-0) → 2-chloro-N-(1-naphthyl)acetamide (832-89-3)

Guidance literature:

With methyllithium lithium bromide; In diethyl ether; at -78 ℃;

DOI:10.1039/c3cc44255a

Reference yield: 68.0%

→ 2-chloro-N-(1-naphthyl)acetamide (832-89-3)

Guidance literature:

With sodium hydrogencarbonate; In dichloromethane; at 20 ℃; for 0.166667h;

In dichloromethane; for 2h; Cooling with ice;

upstream raw materials:

1-amino-naphthalene

chloroacetyl chloride

Chloroiodomethane

1-Naphthyl isocyanate

Downstream raw materials:

(4-methyl-piperazino)-acetic acid-[1]naphthylamide

4-Amino-2-methylthio-N-α-naphthyl)-5-thiazolcarboxamid)

5-morpholin-4-yl-4-phenyl-thiophene-2-carboxylic acid naphthalen-1-yl-amide

Refernces

• 1、 McMahon, Brian,Mauer, Peter,McCoy, Colin P.,Lee, T. Clive,Gunnlaugsson, Thorfinnur. "Selective imaging of damaged bone structure (microcracks) using a targeting supramolecular Eu(III) complex as a lanthanide luminescent contrast agent". . p. 17542 - 17543. Retrieved 2009.
• 2、 Lee, Hong Gyu,Lee, Ju Hoon,Jang, Seung Pyo,Hwang, In Hong,Kim, Sung-Jin,Kim, Youngmee,Kim, Cheal,Harrison, Roger G.. "Zinc selective chemosensors based on the flexible dipicolylamine and quinoline". . p. 542 - 551. Retrieved 2013.
• 3、 Tommasi. "-". . p. 21. Retrieved 1873.
• 4、 Abdel Gawad, Nagwa M.,El Kerdawy, Ahmed M.,George, Riham F.,Georgey, Hanan H.,Mohamed, Abdalla R.. "Design, synthesis and in silico insights of new 7,8-disubstituted-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione derivatives with potent anticancer and multi-kinase inhibitory activities". . . Retrieved 2021/01/04.
• 5、 Li, Qi,Chen, Ying,Xing, Shuaishuai,Liao, Qinghong,Xiong, Baichen,Wang, Yuanyuan,Lu, Weixuan,He, Siyu,Feng, Feng,Liu, Wenyuan,Chen, Yao,Sun, Haopeng. "Highly Potent and Selective Butyrylcholinesterase Inhibitors for Cognitive Improvement and Neuroprotection". . p. 6856 - 6876. Retrieved 2021/05/29.