1-(3-METHOXYPHENYL)-2,5-DIHYDRO-1H-PYRROLE-2,5-DIONE

Base Information

• Chemical Name: 1-(3-METHOXYPHENYL)-2,5-DIHYDRO-1H-PYRROLE-2,5-DIONE
• CAS No.: 3007-23-6
• Molecular Formula: C11H9 N O3
• Molecular Weight: 203.197
• Hs Code.: 2925190090
• Mol file: 3007-23-6.mol

Synonyms:Maleimide,N-(m-methoxyphenyl)- (7CI,8CI); N-(3-Methoxyphenyl)maleimide;N-m-Anisylmaleimide; NSC 209956

Chemical Property of 1-(3-METHOXYPHENYL)-2,5-DIHYDRO-1H-PYRROLE-2,5-DIONE

Chemical Property:

• Vapor Pressure: 2.54E-05mmHg at 25°C
• Melting Point: 62℃
• Boiling Point: 358.5°Cat760mmHg
• Flash Point: 170.6°C
• PSA: 46.61000
• Density: 1.317g/cm³
• LogP: 1.18960

Purity/Quality:

98%min ^*data from raw suppliers

1-(3-Methoxyphenyl)-1H-pyrrole-2,5-dione ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.; R36/37/38:Irritating to eyes, respiratory system
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S36/37/39:Wear suitabl

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(3-METHOXYPHENYL)-2,5-DIHYDRO-1H-PYRROLE-2,5-DIONE

There total 5 articles about 1-(3-METHOXYPHENYL)-2,5-DIHYDRO-1H-PYRROLE-2,5-DIONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

Maleinsaeure-mono-3-methoxy-anilid (31460-27-2,306935-71-7) → N-(3-methoxyphenyl)maleimide (3007-23-6)

Guidance literature:

With sodium acetate; acetic anhydride; In diethyl ether; at 95 - 100 ℃;

DOI:10.1080/10426509308034412

Reference yield:

3-(3-methoxy-phenylcarbamoyl)-acrylic acid (31460-27-2,306935-71-7) → N-(3-methoxyphenyl)maleimide (3007-23-6)

Guidance literature:

With sodium acetate; In acetic anhydride; at 120 ℃; for 0.5h; Microwave irradiation;

DOI:10.1016/j.ejmech.2020.112115

Reference yield:

maleic anhydride (108-31-6) + m-Anisidine (536-90-3,918666-97-4) → N-(3-methoxyphenyl)maleimide (3007-23-6)

Guidance literature:

maleic anhydride; m-Anisidine; In diethyl ether; at 20 ℃;

With sodium acetate; acetic anhydride; at 120 ℃;

DOI:10.1016/j.bmcl.2010.03.040

upstream raw materials:

Maleinsaeure-mono-3-methoxy-anilid

maleic anhydride

m-Anisidine

3-(3-methoxy-phenylcarbamoyl)-acrylic acid

Downstream raw materials:

C₃₀H₄₅N₃O₄

C₂₈H₂₁NO₆

Refernces

• 1、 Li, Shanshan,Song, Gao,Wang, Liang-Liang,Weng, Zhiying,Xu, Guowei,Yang, Weimin,Yang, Yanming,Yang, Yaqing,Zhang, Jiajun,Zuo, Zhili. "The discovery, design and synthesis of potent agonists of adenylyl cyclase type 2 by virtual screening combining biological evaluation". . . Retrieved 2020/02/27.
• 2、 Chen, Hai-Jun,Liu, Yong,Wang, Li-Na,Shen, Qiang,Li, Jia,Nan, Fa-Jun. "Discovery and structural optimization of pyrazole derivatives as novel inhibitors of Cdc25B". scheme or table. p. 2876 - 2879. Retrieved 2010/07/04.