6-CHLOROBENZOTHIAZOLE

Base Information

• Chemical Name: 6-CHLOROBENZOTHIAZOLE
• CAS No.: 2942-10-1
• Molecular Formula: C7H4ClNS
• Molecular Weight: 169.634
• Hs Code.: 29342000
• Mol file: 2942-10-1.mol

Synonyms:6-Chlorobenzothiazole;NSC 522957;6-Chloro-1,3-benzothiazole;

Chemical Property of 6-CHLOROBENZOTHIAZOLE

Chemical Property:

• Vapor Pressure: 0.0131mmHg at 25°C
• Melting Point: 41 °C
• Refractive Index: 1.695
• Boiling Point: 267.8 °C at 760 mmHg
• PKA: 0.21±0.10(Predicted)
• Flash Point: 115.8 °C
• PSA: 41.13000
• Density: 1.435 g/cm³
• LogP: 2.94970
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

6-Chlorobenzo[d]thiazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-CHLOROBENZOTHIAZOLE

There total 2 articles about 6-CHLOROBENZOTHIAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2-amino-5-chlorobenzenethiol (23474-98-8) + carbon dioxide (124-38-9,18923-20-1) → 6-chloro-1,3-benzothiazole (2942-10-1)

Guidance literature:

With Triethoxysilane; 3-butyl-1-methylimidazolium acetate; In N,N-dimethyl-formamide; at 60 ℃; for 24h; under 3750.38 Torr;

DOI:10.1021/acscatal.5b01874

Reference yield:

2-amino-5-chlorobenzenethiol (23474-98-8) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 6-chloro-1,3-benzothiazole (2942-10-1)

Guidance literature:

With H₂SiEt₂; carbon dioxide; tris(pentafluorophenyl)borate; at 120 ℃; for 24h;

DOI:10.1039/c6nj01721e

Reference yield: 95.0%

6-chloro-1,3-benzothiazole (2942-10-1) → 2-amino-5-chlorobenzenesulfonic acid (133-74-4)

Guidance literature:

With [RuCl(P(C₆H₅)3)2(O(C₆H₄)NCH(C₄H₃N))]; bromamine B; sodium hydroxide; In water; acetonitrile; at 39.84 ℃; for 5.5h;

DOI:10.1016/j.molcata.2010.06.006

upstream raw materials:

2-amino-5-chlorobenzenethiol

carbon dioxide

N,N-dimethyl-formamide

Downstream raw materials:

1-(6-chlorobenzo[d]thiazol-2-yl)ethan-1-one

6-chloro-7-nitro-1,3-benzothiazole

2-amino-5-chlorobenzenethiol

2-[(2-amino-5-chlorophenyl)dithio]-4-chlorophenylamine

Refernces

• 1、 Gao, Xiang,Yu, Bo,Mei, Qingqing,Yang, Zhenzhen,Zhao, Yanfei,Zhang, Hongye,Hao, Leiduan,Liu, Zhimin. "Atmospheric CO2 promoted synthesis of N-containing heterocycles over B(C6F5)3 catalyst". . p. 8282 - 8287. Retrieved 2016/10/11.