alpha-Narcotinediol

Base Information Edit

Chemical Name:alpha-Narcotinediol
CAS No.:23942-99-6
Molecular Formula:C22H27 N O7
Molecular Weight:417.459
Hs Code.:
ChEMBL ID:CHEMBL4648869
Nikkaji Number:J38.651K
Mol file:23942-99-6.mol

Synonyms:alpha-narcotinediol

Suppliers and Price of alpha-Narcotinediol

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Medical Isotopes, Inc.
(-)-α-Narcotinediol
100 mg
$ 2200.00

Total 5 raw suppliers

Chemical Property of alpha-Narcotinediol Edit

Chemical Property:

Melting Point:130-132 °C(Solv: ethyl acetate (141-78-6); ethyl ether (60-29-7))
Boiling Point:570.3°Cat760mmHg
PKA:13.25±0.20(Predicted)
Flash Point:298.7°C
PSA：89.85000
Density:1.3g/cm³
LogP:2.13390
XLogP3:1.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:6
Exact Mass:417.17875220
Heavy Atom Count:30
Complexity:566

Purity/Quality:

99% ^*data from raw suppliers

(-)-α-Narcotinediol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1CCC2=CC3=C(C(=C2C1C(C4=C(C(=C(C=C4)OC)OC)CO)O)OC)OCO3
Isomeric SMILES:CN1CCC2=CC3=C(C(=C2[C@@H]1[C@H](C4=C(C(=C(C=C4)OC)OC)CO)O)OC)OCO3
Uses (-)-α-Narcotinediol is a Narcotine derivative, a noscapinoid class of microtubule binding compounds that alter microtubule dynamics without affecting tubulin polymer mass. Noscapinoids show great promise as chemotherapeutic agents for the treatment of human cancers. Unlike Narcotine, (-)-α-Narcotinediol deos not inhibit small-intestinal transport in rats.

Technology Process of alpha-Narcotinediol

There total 6 articles about alpha-Narcotinediol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 106982-93-8
(+)-papaveroxinoline

: 23942-99-6
(-)-α-narcotinediol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; for 1h; Ambient temperature;

Reference yield: 80.0%

: 128-62-1
noscapine

: 23942-99-6
(-)-α-narcotinediol

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; at 35 ℃; for 2h;

Reference yield:

: 106982-95-0
narcotinediol diacetate

: 23942-99-6
(-)-α-narcotinediol

Guidance literature:: Multi-step reaction with 2 steps

1: 73 percent / 6 M HCl / aq. ethanol / Ambient temperature; 3-5 d

2: 96 percent / LiAlH₄ / tetrahydrofuran / 1 h / Ambient temperature

With hydrogenchloride; lithium aluminium tetrahydride; In tetrahydrofuran; ethanol;