N-cyclopropyl-4-hydroxybenzamide

Base Information

• Chemical Name: N-cyclopropyl-4-hydroxybenzamide
• CAS No.: 860298-71-1
• Molecular Formula: C10H11NO2
• Molecular Weight: 177.203
• Hs Code.: 2924297099
• Mol file: 860298-71-1.mol

Synonyms:N-cyclopropyl-4-hydroxybenzamide;

Chemical Property of N-cyclopropyl-4-hydroxybenzamide

Chemical Property:

• PSA: 49.33000
• LogP: 1.67530

Purity/Quality:

99% ^*data from raw suppliers

N-cyclopropyl-4-hydroxybenzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-cyclopropyl-4-hydroxybenzamide

There total 2 articles about N-cyclopropyl-4-hydroxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

Cyclopropylamine (765-30-0) + 4-hydroxy-benzoic acid (99-96-7) → N-cyclopropyl-4-hydroxybenzamide (860298-71-1)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield: 68.0%

→ N-cyclopropyl-4-hydroxybenzamide (860298-71-1)

Guidance literature:

Reference yield: 86.0%

N-cyclopropyl-4-hydroxybenzamide (860298-71-1) + 6-chloronicotinylaldehyde (23100-12-1) → N-cyclopropyl-4-(5-formyl-pyridin-2-yloxy)-benzamide (926305-07-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 1.5h;

upstream raw materials:

Cyclopropylamine

4-hydroxy-benzoic acid

Downstream raw materials:

C₁₄H₁₁ClFN₃O₂

N-cyclopropyl-4-(5-formyl-pyridin-2-yloxy)-benzamide

N-cyclopropyl-4-(5-formyl-6-methyl-pyridin-2-yloxy)-benzamide

4-(benzyloxy)-N-cyclopropylbenzamide

Refernces

• 1、 -. "CHEMOKINE RECEPTOR BINDING COMPOUNDS". Page/Page column 25; 70. . Retrieved 2010/11/26.
• 2、 -. "NON-NUCLEOTIDE REVERSE TRANSCRIPTASE INHIBITORS". Page/Page column 42. . Retrieved 2008/06/13.