Hexanedioic acid, 2-(hydroxyimino)-3-oxo-, diethyl ester

Base Information

• Chemical Name: Hexanedioic acid, 2-(hydroxyimino)-3-oxo-, diethyl ester
• CAS No.: 868-10-0
• Molecular Formula: C10H15NO6
• Molecular Weight: 245.232
• Mol file: 868-10-0.mol

Synonyms:2-[(Z)-Hydroxyimino]-3-oxo-hexanedioic acid diethyl ester;

Chemical Property of Hexanedioic acid, 2-(hydroxyimino)-3-oxo-, diethyl ester

Chemical Property:

• PSA: 102.26000
• LogP: 0.29210

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Hexanedioic acid, 2-(hydroxyimino)-3-oxo-, diethyl ester

There total 4 articles about Hexanedioic acid, 2-(hydroxyimino)-3-oxo-, diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

diethyl 3-oxoadipate (7149-59-9) → 2-hydroxyimino-3-oxo-adipic acid diethyl ester (868-10-0)

Guidance literature:

With acetic acid; sodium nitrite; In water; at 0 ℃;

Reference yield:

cycl-isopropylidene malonate (2033-24-1) → 2-hydroxyimino-3-oxo-adipic acid diethyl ester (868-10-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 0.25 h / 20 °C

1.2: Reflux

2.1: Reflux

3.1: acetic acid; sodium nitrite / water / 0 - 5 °C

With dmap; acetic acid; dicyclohexyl-carbodiimide; sodium nitrite; In dichloromethane; water;

Reference yield:

4-(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-yl)-4-oxo-butyric acid methyl ester (81803-80-7) → 2-hydroxyimino-3-oxo-adipic acid diethyl ester (868-10-0)

Guidance literature:

Multi-step reaction with 2 steps

1: Reflux

2: acetic acid; sodium nitrite / water / 0 - 5 °C

With acetic acid; sodium nitrite; In water;

upstream raw materials:

diethyl 3-oxoadipate

cycl-isopropylidene malonate

4-(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-yl)-4-oxo-butyric acid methyl ester

Downstream raw materials:

5-aminolevulinic acid hydrochloride

benzyl 5-formyl-3-(2-methoxycarbonylethyl)-4-methoxycarbonylmethyl<5-13C>pyrrole-2-carboxylate

benzyl 3-(2-methoxycarbonylethyl)-4-methoxycarbonylmethyl-5-methyl<5-13C>pyrrole-2-carboxylate

Refernces

• 1、 -. "BENZOXAZEPINE COMPOUND". Page/Page column 27. . Retrieved 2010/11/08.