2-Pentenoic acid, 2-cyano-4-methyl-, ethyl ester

Base Information

• Chemical Name: 2-Pentenoic acid, 2-cyano-4-methyl-, ethyl ester
• CAS No.: 868-47-3
• Molecular Formula: C₉H₁₃NO₂
• Molecular Weight: 167.208
• Mol file: 868-47-3.mol

Synonyms:2-Pentenoic acid, 2-cyano-4-methyl-, ethyl ester

Chemical Property of 2-Pentenoic acid, 2-cyano-4-methyl-, ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Pentenoic acid, 2-cyano-4-methyl-, ethyl ester

There total 1 articles about 2-Pentenoic acid, 2-cyano-4-methyl-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

ethenetetracarbonitrile (670-54-2) + C32H44P4Re(1+)*C12H11NO2*C5H6NO2(1-) → ethyl 2-cyano-4-methylpent-2-enoate (93222-76-5,125027-35-2,868-47-3) + Benzylidenemalononitrile (2700-22-3) + ethyl tricyanoethylenecarboxylate (153814-39-2)

Guidance literature:

In tetrahydrofuran; Product distribution;

DOI:10.1016/S0022-328X(98)00768-2

Reference yield: 92.0%

2-vinylidenesuccinic acid diethyl ester (865714-07-4) + ethyl 2-cyano-4-methylpent-2-enoate (93222-76-5,125027-35-2,868-47-3) → (1R,2R,6R)-triethyl 1-cyano-6-isopropylcyclohex-3-ene-1,2,3-tricarboxylate (1372800-81-1)

Guidance literature:

ethyl 2-cyano-4-methylpent-2-enoate; With N-((2S,3S)-1-(diphenylphosphino)-3-methylpentan-2-yl)-3,5-difluorobenzamide; In 1,2-dichloro-ethane; at -18 ℃; for 0.166667h;

2-vinylidenesuccinic acid diethyl ester; In 1,2-dichloro-ethane; at -18 ℃; for 3h; optical yield given as %ee; enantioselective reaction;

DOI:10.1039/c2ob25295c

Reference yield: 74.0%

potassium cyanide + ethyl 2-cyano-4-methylpent-2-enoate (93222-76-5,125027-35-2,868-47-3) → isopropylsuccinonitrile (1115-37-3)

Guidance literature:

In ethanol; water; at 20 ℃; Reflux;

upstream raw materials:

ethenetetracarbonitrile

Downstream raw materials:

malonic acid

2-cyano-3-isopropyl-glutaric acid diethyl ester

isopropylsuccinonitrile

ethyl 2-cyano-4-methylpentanoate

Refernces