7-Chloro-4-hydrazinoquinoline

Base Information

• Chemical Name: 7-Chloro-4-hydrazinoquinoline
• CAS No.: 23834-14-2
• Molecular Formula: C9H8 Cl N3
• Molecular Weight: 193.636
• Hs Code.: 2933990090
• European Community (EC) Number: 628-226-0
• NSC Number: 10802
• DSSTox Substance ID: DTXSID80178539
• Nikkaji Number: J120.980I
• Wikidata: Q83048979
• ChEMBL ID: CHEMBL3423374
• Mol file: 23834-14-2.mol

Synonyms:7-Chloro-4-hydrazinoquinoline;23834-14-2;7-chloro-4-hydrazinylquinoline;QUINOLINE, 7-CHLORO-4-HYDRAZINO-;(7-chloroquinolin-4-yl)hydrazine;C9H8ClN3;BRN 0141468;4-Hydrazino-7-chloroquinoline;(7-chloro-4-quinolyl)hydrazine;1-(7-chloro-4-quinolyl)hydrazine;4-22-00-07045 (Beilstein Handbook Reference);NSC10802;SCHEMBL2455864;7-chloroquinolin-4-yl-hydrazine;CHEMBL3423374;DTXSID80178539;HMS1786E14;(7-chloro-quinolin-4-yl)-hydrazine;AB8882;BBL027609;MFCD00006776;NSC 10802;NSC-10802;STL163512;7-Chloro-4-hydrazinoquinoline, 98%;AKOS000119445;SB67548;LS-141747;FT-0621379;EN300-17253;3E-912;A816930;J-015233;Z56899192

Chemical Property of 7-Chloro-4-hydrazinoquinoline

Chemical Property:

• Vapor Pressure: 4.8E-07mmHg at 25°C
• Melting Point: 219-225oC (dec.)(lit.)
• Boiling Point: 413.5°Cat760mmHg
• PKA: 6.70±0.50(Predicted)
• Flash Point: 203.8°C
• PSA: 50.94000
• Density: 1.43g/cm³
• LogP: 2.94710
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 193.0406750
• Heavy Atom Count: 13
• Complexity: 176

Purity/Quality:

98%min ^*data from raw suppliers

7-chloro-4-hydrazinoquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC2=C(C=CN=C2C=C1Cl)NN
• Uses: 7-Chloro-4-hydrazinoquinoline was used in the preparation of new Schiff base hydrazone ligand via reaction with o-hydroxybenzaldehyde. It was also used in the preparation of N′-(E)-heteroaromatic-isonicotinohydrazide derivatives and the heteroaromatic 7-chloro-4-quinolinylhydrazone derivatives.

Technology Process of 7-Chloro-4-hydrazinoquinoline

There total 2 articles about 7-Chloro-4-hydrazinoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4,7-dichloroquinoline (86-98-6,1138471-54-1) → 7-chloro-4-hydrazinoquinoline (23834-14-2)

Guidance literature:

With hydrazine hydrate; at 90 ℃; for 12h;

DOI:10.1016/j.ejps.2019.04.016

Reference yield:

→ 7-chloro-4-hydrazinoquinoline (23834-14-2)

Guidance literature:

4,7-Dichlorchinolin, N2H4*H2O (915, 920);

Reference yield: 92.0%

7-chloro-4-hydrazinoquinoline (23834-14-2) + 4-fluorobenzaldehyde (459-57-4) → 7-chloro-4-(2-(4-fluorobenzylidene)hydrazinyl)quinoline (71429-16-8)

Guidance literature:

In ethanol; for 0.0416667h; Sonication;

DOI:10.2174/1570180814666161121120414

upstream raw materials:

4,7-dichloroquinoline

Downstream raw materials:

4-azido-7-chloro-quinoline

4-[3-(4-chlorophenyl)-5-hydroxy-5-trifluoromethyl-4,5-dihydro-1H-pyrazol-1-yl]-7-chloroquinoline

4-[5-hydroxy-3-(4-methoxyphenyl)-5-trifluoromethyl-4,5-dihydro-1H-pyrazol-1-yl]-7-chloroquinoline

4-[3-(4-biphenyl)-5-hydroxy-5-trifluoromethyl-4,5-dihydro-1H-pyrazol-1-yl]-7-chloroquinoline

Refernces

• 1、 Salve, Preeti S.,Alegaon, Shankar G.,Sriram, Dharmarajan. "Three-component, one-pot synthesis of anthranilamide Schiff bases bearing 4-aminoquinoline moiety as Mycobacterium tuberculosis gyrase inhibitors". . p. 1859 - 1866. Retrieved 2017.
• 2、 Singh, Atamjit,Kaur, Harneetpal,Arora, Saroj,Bedi, Preet Mohinder Singh. "Design, synthesis, and biological evaluation of novel morpholinated isatin–quinoline hybrids as potent anti-breast cancer agents". . . Retrieved 2021/11/17.
• 3、 Marinho, Juliane Aparecida,Martins Guimar?es, Daniel Silqueira,Glanzmann, Nícolas,de Almeida Pimentel, Giovana,Karine da Costa Nunes, Izabelle,Gualberto Pereira, Henrique Marcelo,Navarro, Maribel,de Pilla Varotti, Fernando,David da Silva, Adilson,Abramo, Clarice. "In vitro and in vivo antiplasmodial activity of novel quinoline derivative compounds by molecular hybridization". . . Retrieved 2021/02/21.