1-TRITYL-1H-IMIDAZOLE-4-METHANOL

Base Information

• Chemical Name: 1-TRITYL-1H-IMIDAZOLE-4-METHANOL
• CAS No.: 33769-07-2
• Molecular Formula: C23H20N2O
• Molecular Weight: 340.425
• Hs Code.: 2933290090
• Mol file: 33769-07-2.mol

Synonyms:Imidazole-4-methanol,1-trityl- (8CI);(1-Trityl-1H-imidazol-4-yl)methanol;1-(Triphenylmethyl)-4-(hydroxymethyl)imidazole;1-Triphenylmethyl-1H-imidazole-4-methanol;1-Triphenylmethylimidazole-4-methanol;NSC 669641;

Chemical Property of 1-TRITYL-1H-IMIDAZOLE-4-METHANOL

Chemical Property:

• Vapor Pressure: 1.77E-11mmHg at 25°C
• Melting Point: 226-232
• Refractive Index: 1.612
• Boiling Point: 516.1 °C at 760 mmHg
• PKA: 13.61±0.10(Predicted)
• Flash Point: 265.9 °C
• PSA: 38.05000
• Density: 1.1 g/cm³
• LogP: 4.21560

Purity/Quality:

98%min ^*data from raw suppliers

(1-Trityl-1H-imidazol-4-yl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-TRITYL-1H-IMIDAZOLE-4-METHANOL

There total 16 articles about 1-TRITYL-1H-IMIDAZOLE-4-METHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-(hydroxymethyl)imidazole hydrochloride + trityl chloride (76-83-5) → 4-(hydroxymethyl)-1-(triphenylmethyl)imidazole (33769-07-2)

Guidance literature:

4-(hydroxymethyl)imidazole hydrochloride; With triethylamine; In N,N-dimethyl-formamide; for 0.166667h;

trityl chloride; In N,N-dimethyl-formamide; Inert atmosphere;

Reference yield: 100.0%

trityl chloride (76-83-5) + 1H-imidazol-5-ylmethanol hydrochloride (32673-41-9) → 4-(hydroxymethyl)-1-(triphenylmethyl)imidazole (33769-07-2)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2006.11.007

Reference yield: 94.0%

(1H-imidazol-4-yl)methanol (822-55-9) + trityl chloride (76-83-5) → 4-(hydroxymethyl)-1-(triphenylmethyl)imidazole (33769-07-2)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

DOI:10.1021/jm990254z

upstream raw materials:

(1H-imidazol-4-yl)methanol

trityl chloride

D-arabinopyranose

formamidine acetic acid

Downstream raw materials:

1-trityl-4-(2-cyanoethyl)imidazole

3-(1-Trityl-1H-imidazol-4-yl)-propionitrile

4-(tert-butyldimethylsilyloxymethyl)-1-(triphenylmethyl)imidazole

C₃₀H₂₃N₃O₅

Refernces

• 1、 -. "ANDROGEN RECEPTOR MODULATORS AND METHODS FOR THEIR USE". Paragraph 0968; 0969. . Retrieved 2020/05/06.
• 2、 Kennedy, David C.,James, Brian R.. "Synthesis and antiproliferatory activity of ruthenium complexes containing N-heterocyclic carboxylates". . p. 32 - 36. Retrieved 2017/03/11.