6,7-Dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline hydrochloride

Base Information

• Chemical Name: 6,7-Dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline hydrochloride
• CAS No.: 63283-42-1
• Molecular Formula: C₁₂H₁₇NO₂*ClH
• Molecular Weight: 243.733
• Hs Code.: 29334990
• European Community (EC) Number: 822-325-4
• NSC Number: 34659
• ChEMBL ID: CHEMBL1883920
• Mol file: 63283-42-1.mol

Synonyms:1-methyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline;salsolidine;salsolidine hydrochloride;salsolidine hydrochloride, (S)-isomer;salsolidine, (S)-isomer

Chemical Property of 6,7-Dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline hydrochloride

Chemical Property:

• Vapor Pressure: 0.000496mmHg at 25°C
• Melting Point: 189-192°C
• Boiling Point: 313.4°C at 760 mmHg
• Flash Point: 127.1°C
• PSA: 30.49000
• LogP: 3.04130
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 243.1026065
• Heavy Atom Count: 16
• Complexity: 210

Purity/Quality:

98%min ^*data from raw suppliers

6,7-Dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinolinium chloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1C2=CC(=C(C=C2CCN1)OC)OC.Cl

Technology Process of 6,7-Dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline hydrochloride

There total 4 articles about 6,7-Dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.9%

6,7-dimethoxy-1-methyl-3,4-dihydroisoquinoline (4721-98-6) → 6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline hydrochloride (63283-42-1)

Guidance literature:

With hydrogen; Pd-BaSO₄; In methanol; at 40 ℃; under 750.06 Torr;

Reference yield: 45.0%

→ 6,7-dimethoxy-1-methyl-3,4-dihydroisoquinoline (4721-98-6) + 6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline hydrochloride (63283-42-1)

Guidance literature:

In tetrahydrofuran; for 48h; Heating;

Reference yield:

N-[2-(3,4-dimethoxyphenyl)ethyl]acetamide (6275-29-2) → 6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline hydrochloride (63283-42-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 64 percent / POCl₃ / toluene / 1 h / Heating

2: 90.9 percent / hydrogen / Pd/BaSO₄ / methanol / 40 °C / 750.06 Torr

With hydrogen; trichlorophosphate; Pd-BaSO₄; In methanol; toluene;

upstream raw materials:

6,7-dimethoxy-1-methyl-3,4-dihydroisoquinoline

N-[2-(3,4-dimethoxyphenyl)ethyl]acetamide

2-(3,4-dimethoxyphenyl)-ethylamine

Downstream raw materials:

6,7-Dihydroxy-1-methyl-1,2,3,4-tetrahydro-isoquinoline monohydrobromide

(+/-)-salsolinol

Refernces

• 1、 Yamada, Koichiro,Takeda, Mikio,Iwakuma, Takeo. "Asymmetric Reduction of Cyclic Imines with Chiral Sodium Acyloxyborohydrides". . p. 265 - 270. Retrieved 2007/10/02.