N-(3-Aminopropyl)morpholine

Base Information

• Chemical Name: N-(3-Aminopropyl)morpholine
• CAS No.: 123-00-2
• Molecular Formula: C7H16N2O
• Molecular Weight: 144.217
• Hs Code.: 29349990
• European Community (EC) Number: 204-590-2
• NSC Number: 1081
• UN Number: 2735
• UNII: 9A09425QD6
• DSSTox Substance ID: DTXSID4041521
• Nikkaji Number: J34.693D
• Wikidata: Q27159240
• Metabolomics Workbench ID: 67789
• ChEMBL ID: CHEMBL158697
• Mol file: 123-00-2.mol

Synonyms:123-00-2;N-(3-Aminopropyl)morpholine;3-Morpholinopropylamine;3-morpholinopropan-1-amine;4-MORPHOLINEPROPANAMINE;N-Aminopropylmorpholine;4-(3-Aminopropyl)morpholine;3-(morpholin-4-yl)propan-1-amine;4-Morpholinepropylamine;1-Amino-3-morpholinopropane;Morpholine, 4-(3-aminopropyl)-;3-(4-Morpholinyl)-1-propanamine;4-Aminopropylmorpholine;(3-Aminopropyl)morpholine;Morpholine, N-aminopropyl-;Morpholine, 4-aminopropyl-;3-morpholin-4-ylpropan-1-amine;3-Morpholin-4-yl-propylamine;3-Morpholinopropanamine;gamma-Morpholinopropylamine;N-(3-Aminopropyl)morfolin;NSC 1081;.gamma.-Morpholinopropylamine;Aminopropylmorpholine;N-(3-aminopropyl)-morpholine;N-(3-Aminopropyl)morfolin [Czech];EINECS 204-590-2;BRN 0105104;3-(4-Morpholinyl)propylamine;N-(3-aminopropyl) morpholine;4-(3-aminopropyl)-morpholine;AI3-52553;DTXSID4041521;UNII-9A09425QD6;CHEBI:86554;Morpholine, N-(3-aminopropyl)-;4-(.gamma.-Aminopropyl)morpholine;NSC-1081;9A09425QD6;4-[3-Aminopropyl]morpholine;4-27-00-00411 (Beilstein Handbook Reference);3-aminopropyl morpholine;3-morpholin-4-ylpropylamine;NSC1081;MFCD00006184;3-aminopropylmorpholine;3-morpholinylpropylamine;3-morpholino-propylamine;N-(aminopropyl)morpholine;(3-morpholinopropyl)amine;4-(aminopropyl)morpholine;bmse000971;bmse000981;3-morpholino-1-propanamine;3-Morpholino-1-propylamine;4-(3Aminopropyl)morpholine;N-(3-aminopropyl)morpholin;1-morpholino-3-aminopropane;3-morpholino-propan-1-amine;Oprea1_150673;SCHEMBL19922;WLN: T6N DOTJ A3Z;3-morpholin-4-yl propylamine;MLS000556422;3-morpholine-4-yl-propylamine;4-(3-aminopropyl) morpholine;3-Morpholinopropylamine, 98%;4-(3-Aninopropyl)-morpholine;(3-morpholin-4-ylpropyl)amine;3-(4-morpholinyl)-propanamine;3-(morpholin-4-yl)propylamine;CHEMBL158697;N-(gamma-aminopropyl)morpholine;3-Morpholinopropylamine, Liquid;DTXCID2021521;[3-(4-morpholinyl)propyl]amine;3-(morpholin-4-yl)-propylamine;3-(N-morpholinyl)-1-propylamine;3-(4-morpholinyl)-1-propylamine;3-(4-Morpholinyl)propan-1-amine;3-morpholin-4-yl-propan-1-amine;HMS2384K03;3-(4-morpholinyl)-1-aminopropane;3-(4-morpholinyl)-propan-1-amine;STR02269;Tox21_302076;STK802951;3-(4-Morpholinyl)-1-propanamine #;AKOS000119857;FD10554;3-(N-MORPHOLINO)-1-AMINOPROPANE;NCGC00246332-01;NCGC00255491-01;CAS-123-00-2;LS-92413;SMR000147739;A0409;A1799;BB 0216500;CS-0008472;FT-0616577;EN300-19625;A850959;Q-201446;Q27159240;F2187-2240;Z104474506;FC1F27D2-1429-41AC-9F03-C277D41006FA

Chemical Property of N-(3-Aminopropyl)morpholine

Chemical Property:

• Appearance/Colour: Clear liquid
• Vapor Pressure: 0.294mmHg at 25°C
• Melting Point: -15 °C(lit.)
• Refractive Index: n20/D 1.4761(lit.)
• Boiling Point: 227.8 °C at 760 mmHg
• PKA: 10.30±0.10(Predicted)
• Flash Point: 98.9 °C
• PSA: 38.49000
• Density: 0.985 g/cm³
• LogP: 0.30560
• Storage Temp.: Store below +30°C.
• Sensitive.: Air Sensitive
• Solubility.: 1000g/l
• Water Solubility.: Soluble
• XLogP3: -0.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 144.126263138
• Heavy Atom Count: 10
• Complexity: 81.7
• Transport DOT Label: Corrosive

Purity/Quality:

99% ^*data from raw suppliers

3-Morpholinopropylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi, C
• Hazard Codes: C,Xi
• Statements: 21-34-21/22-36/37-R34-R21/22
• Safety Statements: 26-36/37/39-45-S45-S36/37/39-S26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1COCCN1CCCN
• Uses: Fiber synthesis; chemical intermediate. 3-(4-Morpholinyl)propylamine is catalytic agent, petrochemical additive. It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs.

Technology Process of N-(3-Aminopropyl)morpholine

There total 17 articles about N-(3-Aminopropyl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-Trimethylsilanyl-ethanesulfonic acid (3-morpholin-4-yl-propyl)-amide (106018-95-5) → 4-(3-Aminopropyl)morpholine (123-00-2)

Guidance literature:

With cesium fluoride; In N,N-dimethyl-formamide; at 95 ℃; for 40h;

DOI:10.1016/S0040-4039(00)84458-5

Reference yield: 86.0%

2-(3-morpholinylpropyl)-1H-isoindole-1,3(2H)-dione (6820-95-7) → 4-(3-Aminopropyl)morpholine (123-00-2)

Guidance literature:

With hydrazine hydrate; In ethanol; for 24h; Reflux;

DOI:10.1016/j.ejmech.2019.01.052

Reference yield: 86.0%

morpholine (110-91-8,99108-56-2) → 4-(3-Aminopropyl)morpholine (123-00-2)

Guidance literature:

Argopore Wang resin-bound 3-amino-1-propanol; With 1H-imidazole; iodine; triphenylphosphine; In N,N-dimethyl-formamide; for 16h;

morpholine; In N,N-dimethyl-formamide; at 50 ℃; for 6h;

With trifluoroacetic acid; In dichloromethane; for 1h;

DOI:10.1021/ol049575h

upstream raw materials:

morpholine

N-(3-chloropropyl)phthalimide

2-(3-bromopropyl)isoindole-1,3-dione

acrylonitrile

Downstream raw materials:

2-(3-morpholinylpropyl)-1H-isoindole-1,3(2H)-dione

1,3,5-tris[3-(morpholin-4-yl)propyl][1,3,5]triazinane

3-(3-morpholino-propylamino)-2,2-diphenyl-propionic acid

3-hydroxy-2,2-diphenyl-propionic acid-(3-morpholino-propylamide)

Refernces

• 1、 Tazarki, Helmi,Zeinyeh, Wael,Esvan, Yannick J.,Knapp, Stefan,Chatterjee, Deep,Schr?der, Martin,Joerger, Andreas C.,Khiari, Jameleddine,Josselin, Béatrice,Baratte, Blandine,Bach, Stéphane,Ruchaud, Sandrine,Anizon, Fabrice,Giraud, Francis,Moreau, Pascale. "New pyrido[3,4-g]quinazoline derivatives as CLK1 and DYRK1A inhibitors: synthesis, biological evaluation and binding mode analysis". . p. 304 - 317. Retrieved 2019/02/07.
• 2、 -. "Two-photon fluorescent probe for detecting nitric oxide near cell membranes". Paragraph 0015. . Retrieved 2018/03/28.