2,2'-DICHLOROBENZILIC ACID

Base Information

• Chemical Name: 2,2'-DICHLOROBENZILIC ACID
• CAS No.: 3152-12-3
• Molecular Formula: C14H10 Cl2 O3
• Molecular Weight: 297.138
• Hs Code.: 2918199090
• Mol file: 3152-12-3.mol

Synonyms:Benzilicacid, 2,2'-dichloro- (7CI,8CI); Bis(2-chlorophenyl)(hydroxy)acetic acid;Bis(2-chlorophenyl)glycolic acid; NSC 310167

Chemical Property of 2,2'-DICHLOROBENZILIC ACID

Chemical Property:

• Melting Point: 160-164 °C(lit.)
• Boiling Point: 480.6°Cat760mmHg
• PKA: 2.95±0.10(Predicted)
• Flash Point: 244.4°C
• PSA: 57.53000
• Density: 1.469g/cm³
• LogP: 3.31390

Purity/Quality:

99% ^*data from raw suppliers

2,2′-Dichlorobenzilic acid 97% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi,N
• Statements: 36/37/38-50/53
• Safety Statements: 26-36-60-61

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 2,2-Bis(2-chlorophenyl)-2-hydroxyacetic Acid is a useful intermediate in the synthesis of substituted benzilic acid derivatives with antimicrobial properties.

Technology Process of 2,2'-DICHLOROBENZILIC ACID

There total 3 articles about 2,2'-DICHLOROBENZILIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2,2'-dichlorobenzil (21854-95-5) → α-(hydroxy)-2-chloro-α-(2-chlorophenyl)benzeneacetic acid (3152-12-3)

Guidance literature:

With potassium hydroxide; Celite; for 0.0125h; Irradiation;

DOI:10.1039/a805255g

Reference yield:

2,2'-dichlorobenzil (21854-95-5) → α-(hydroxy)-2-chloro-α-(2-chlorophenyl)benzeneacetic acid (3152-12-3)

Guidance literature:

at 60.5 ℃; Umlagerung durch basen;

Reference yield:

→ α-(hydroxy)-2-chloro-α-(2-chlorophenyl)benzeneacetic acid (3152-12-3)

Guidance literature:

aus 2-Chlor-benzaldehyd ueber 2.2'-Dichlor-benzoin u. 2.2'-Dichlor-benzil;

upstream raw materials:

2,2'-dichlorobenzil

Downstream raw materials:

N-{3-[l-(3-{[bis(2-chlorophenyl)(hydroxy)acetyl]amino}propyl)-4-piperidinyl]-4-methylphenyl}-2-methylpropanamide

1-[bis-(2-chloro-phenyl)-hydroxy-acetyl]-4-methyl-piperazine

2,2'-dichloro-benzophenone-(2,4-dinitro-phenylhydrazone)

α-(acetyloxy)-2-chloro-α-(2-chlorophenyl)benzeneacetic acid, methyl ester

Refernces

• 1、 Yu, Hui-Ming,Chen, Same-Ting,Tseng, Min-Jen,Chen, Shui-Tein,Wang, Kung-Tsung. "Microwave-assisted heterogeneous benzil-benzilic acid rearrangement". . p. 62 - 63. Retrieved 2007/10/03.