4-Nitropyridine

Base Information

• Chemical Name: 4-Nitropyridine
• CAS No.: 1122-61-8
• Molecular Formula: C5H4N2O2
• Molecular Weight: 124.099
• Hs Code.: 2933399090
• Mol file: 1122-61-8.mol

Synonyms:NSC 30350;

Chemical Property of 4-Nitropyridine

Chemical Property:

• Vapor Pressure: 0.0961mmHg at 25°C
• Melting Point: 51-54°C(lit.)
• Refractive Index: 1.567
• Boiling Point: 231.136 °C at 760 mmHg
• PKA: 1.61(at 25℃)
• Flash Point: 93.588 °C
• PSA: 58.71000
• Density: 1.313 g/cm³
• LogP: 1.51300
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Nitropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Nitropyridine

There total 15 articles about 4-Nitropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-nitraminopyridine N-oxide (1124-33-0) → 4-nitropyridine (1122-61-8)

Guidance literature:

With methyloxorhenium(V)(2-(mercaptomethyl)thiophenolate) triphenylphosphine; triphenylphosphine; In benzene; at 20 ℃; for 6h;

DOI:10.1021/ol006595k

Reference yield: 57.0%

4-lithiopyridine (54750-97-9) → 4-nitropyridine (1122-61-8)

Guidance literature:

With dinitrogen tetraoxide; In tetrahydrofuran; -190 deg C -> room temperature;

DOI:10.1021/ja963658e

Reference yield: 51.0%

4-aminopyridine (504-24-5) → 4-nitropyridine (1122-61-8)

Guidance literature:

With sulfuric acid; dihydrogen peroxide; at 0 - 20 ℃;

DOI:10.1002/jlcr.730

upstream raw materials:

4-aminopyridine

4-nitraminopyridine N-oxide

4-lithiopyridine

sulfuric acid

Downstream raw materials:

4-piperidinylpyridine

4-ethoxypyridine

1-(4'-pyridyl)-4-pyridone

trans-4,4'-azobis(pyridine)

Refernces

• 1、 Karramkam,Hinnen,Vaufrey,Dolle. "2-, 3- and 4-[18F]fluoropyridine by no-carrier-added nucleophilic aromatic substitution with K[18F]F-K222 - A comparative study". . p. 979 - 992. Retrieved 2003.
• 2、 Wan, Zhidong,Fang, Zheng,Yang, Zhao,Liu, Chengkou,Gu, Jiajia,Guo, Kai. "A two-step continuous flow synthesis of 4-nitropyridine". . p. 209 - 212. Retrieved 2015.
• 3、 Ezumi et al.. "". . p. 2397. Retrieved 1970.
• 4、 -. "Synthetic method of 4-pyridylaldehyde". Paragraph 0032; 0033; 0038; 0043. . Retrieved 2017/11/18.