1-(4-hydroxybenzyl)pyrazole

Base Information

• Chemical Name: 1-(4-hydroxybenzyl)pyrazole
• CAS No.: 80200-09-5
• Molecular Formula: C10H10N2O
• Molecular Weight: 174.202
• Mol file: 80200-09-5.mol

Synonyms:4-Hobp;Phenol,4-(1H-pyrazol-1-ylmethyl);4-[(1-pyrazolyl)methyl]phenol;1-(4-Hydroxybenzyl)pyrazole;

Chemical Property of 1-(4-hydroxybenzyl)pyrazole

Chemical Property:

• Vapor Pressure: 7.83E-06mmHg at 25°C
• Boiling Point: 364.8°Cat760mmHg
• Flash Point: 174.4°C
• PSA: 38.05000
• Density: 1.16g/cm³
• LogP: 1.63700

Purity/Quality:

95+% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-hydroxybenzyl)pyrazole

There total 5 articles about 1-(4-hydroxybenzyl)pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

NH-pyrazole (288-13-1) + (4-hydroxyphenyl)methanol (623-05-2) → 4-((1H-pyrazol-1-yl)methyl)phenol (80200-09-5)

Guidance literature:

In water; at 120 ℃; for 12h; Microwave irradiation; Sealed tube;

DOI:10.1002/ejoc.201701183

Reference yield: 85.0%

4-((1H-pyrazol-1-yl)methyl)aniline (142335-61-3) → 4-((1H-pyrazol-1-yl)methyl)phenol (80200-09-5)

Guidance literature:

With sulfuric acid; sodium nitrite; In water; at 0 - 85 ℃; for 0.833333h;

Reference yield:

4-nitrobenzyl chloride (100-14-1) → 4-((1H-pyrazol-1-yl)methyl)phenol (80200-09-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 61 percent / K₂CO₃ / butan-2-one / 46 h / Heating

2: 95 percent / H₂ / 5percent Pd/C / aq. ethanol / 760 Torr / Ambient temperature

3: 85 percent / 3M H₂SO₄, NaNO₂ / H₂O / 0.83 h / 0 - 85 °C

With sulfuric acid; hydrogen; potassium carbonate; sodium nitrite; palladium on activated charcoal; In ethanol; water; butanone;

upstream raw materials:

NH-pyrazole

(4-hydroxyphenyl)methanol

4-((1H-pyrazol-1-yl)methyl)aniline

4-nitrobenzyl chloride

Downstream raw materials:

3-[4-(1-pyrazolyl)methylphenoxy]propyl bromide

1-isopropylamino-3-[4-[(1-pyrazolyl)methyl]phenoxy]-2-propanol

2-(4-Pyrazol-1-ylmethyl-phenoxy)-propionic acid ethyl ester

Refernces

• 1、 -. "Ether compounds, their use, and intermediates for use in their production". . . Retrieved 2008/06/13.
• 2、 Machin, Peter J.,Hurst, David N.,Bradshaw, Rachel M.,Blaber, Leslie C.,Burden, David T.,Melarange, Rosemary A.. "β1-Selective Adrenoceptor Antagonists. 3. 4-Azolyl-Linked Phenoxypropanolamines". . p. 503 - 509. Retrieved 2007/10/02.