Cyclobutane-1,2-dicarboxylic acid

Base Information

• Chemical Name: Cyclobutane-1,2-dicarboxylic acid
• CAS No.: 3396-14-3
• Molecular Formula: C6H8 O4
• Molecular Weight: 144.127
• Hs Code.: 2917209090
• European Community (EC) Number: 222-249-6
• NSC Number: 527264
• DSSTox Substance ID: DTXSID50871828
• Nikkaji Number: J80.714A
• Mol file: 3396-14-3.mol

Synonyms:cyclobutane-1,2-dicarboxylic acid;3396-14-3;1,2-Cyclobutanedicarboxylic acid;USAF ST-3;trans-1,2-Cyclobutanedicarboxylic acid;EINECS 214-392-8;EINECS 222-249-6;NSC 527264;AI3-50496;1,2-CYCLOBUTANEDICARBOXYLIC ACID, (E)-;MFCD00019263;cyclobutane-1,2-dicarboxylicacid;TRANS-CYCLOBUTANE-1,2-DICARBOXYLICACID;(1R,2S)-rel-Cyclobutane-1,2-dicarboxylic acid;SCHEMBL339332;WLN: L4TJ AVQ BVQ -T;AMY7475;DTXSID50871828;MFCD13196659;NSC527264;AKOS015966505;EX-A3316-7;NSC-527264;SB11036;SB13016;SB22487;AS-40796;LS-55874;SY096913;CS-0049639;FT-0633566;FT-0694296;FT-0701294;EN300-72287;J-520131

Chemical Property of Cyclobutane-1,2-dicarboxylic acid

Chemical Property:

• Boiling Point: 377.7°Cat760mmHg
• PKA: 4.08±0.40(Predicted)
• Flash Point: 196.4°C
• PSA: 74.60000
• Density: 1.509g/cm³
• LogP: 0.18180
• XLogP3: -0.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 144.04225873
• Heavy Atom Count: 10
• Complexity: 155

Purity/Quality:

98%,99%, ^*data from raw suppliers

Cyclobutane-1,2-dicarboxylicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(C1C(=O)O)C(=O)O

Technology Process of Cyclobutane-1,2-dicarboxylic acid

There total 46 articles about Cyclobutane-1,2-dicarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,3,4,4-Tetrachloro-cyclobut-1-ene-1,2-dicarboxylic acid (89799-95-1) → cis-cyclobutane-1,2-dicarboxylic acid (1124-13-6,3396-14-3,17224-72-5,58616-94-7,58616-97-0,1461-94-5)

Guidance literature:

With hydrogen; platinum(IV) oxide; In water;

Reference yield:

cyclobutane-1,1,2,2-tetracarboxylic acid → cis-cyclobutane-1,2-dicarboxylic acid (1124-13-6,3396-14-3,17224-72-5,58616-94-7,58616-97-0,1461-94-5)

Guidance literature:

at 180 ℃; Behandeln mit Acetylchlorid und Kochen des erhaltenen Anhydrids mit Wasser;

Reference yield:

dimethyl 1-cyanocyclobutane-1,2-dicarboxylate (14132-45-7) → cis-cyclobutane-1,2-dicarboxylic acid (1124-13-6,3396-14-3,17224-72-5,58616-94-7,58616-97-0,1461-94-5)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. HCl / 12 h / Heating

2: 180 °C / water pump

With hydrogenchloride;

DOI:10.1016/S0957-4166(02)00757-7

upstream raw materials:

cis-1,2-divinylcyclobutane

1,2-bis-methanesulfonyl-cyclobutane-1,2-dicarboxylic acid diamide

all-cis-3,4-Dibrom-cyclobutan-dicarbonsaeure-(1,2)-anhydrid

3,3,4,4-Tetrachloro-cyclobut-1-ene-1,2-dicarboxylic acid

Downstream raw materials:

3-oxabicyclo[3.2.0]heptane-2,4-dione

(+/-)-(1S,2S)-cyclobutane-1,2-dicarboxylic acid

(+/-)-cis-2-benzoyl-cyclobutane-carboxylic acid-⁽¹⁾

trans-(cyclobutane-1,2-diyl)dimethanol

Refernces

• 1、 -. "MACROCYCLIC SPIROETHERS AS MCL-1 INHIBITORS". Paragraph 0747; 0748. . Retrieved 2020/07/31.
• 2、 Earl, Harold A.,Stirling, Charles J. M.. "Elimination and Addition Reactions. Part 43. Eliminative Fission of Cyclobutanes and the Relationship between Strain and Reactivity in Cyclobutanes and Cyclopropanes". . p. 1273 - 1280. Retrieved 2007/10/02.