1-NITROADAMANTANE

Base Information

• Chemical Name: 1-NITROADAMANTANE
• CAS No.: 7575-82-8
• Molecular Formula: C10H15NO2
• Molecular Weight: 181.235
• Mol file: 7575-82-8.mol

Synonyms:Adamantane,1-nitro- (6CI,7CI,8CI);1-Nitroadamantane;NSC 130990;NSC 235788;

Chemical Property of 1-NITROADAMANTANE

Chemical Property:

• Vapor Pressure: 0.00463mmHg at 25°C
• Melting Point: 159℃
• Refractive Index: 1.545
• Boiling Point: 277.1 °C at 760 mmHg
• Flash Point: 121.8 °C
• PSA: 45.82000
• Density: 1.19 g/cm³
• LogP: 2.75510
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility.: Chloroform (Slightly), Methanol (Sparingly)

Purity/Quality:

98%min ^*data from raw suppliers

1-Nitroadamantane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-Nitroadamantane is a biologically active polycycloalkane that exhibits antiviral activities and as well as inhibitory activities towards the poliferation of lymphocytes.

Technology Process of 1-NITROADAMANTANE

There total 22 articles about 1-NITROADAMANTANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

adamantane (281-23-2) → 1-adamanthanol (768-95-6) + 1-nitroadamantane (7575-82-8) + 1-nitroxyadamantane (32314-61-7)

Guidance literature:

With Nitrogen dioxide; ozone; In dichloromethane; at -78 ℃; for 0.5h;

DOI:10.1039/cc9960001783

Reference yield: 74.0%

adamantane (281-23-2) → 1-adamantyl fluoride (768-92-3) + 1-hydroxy-3-fluoroadamante (58652-35-0) + 1-adamanthanol (768-95-6) + 1-nitroadamantane (7575-82-8)

Guidance literature:

With nitronium tetrafluoborate; In various solvent(s); Further byproducts given; Ambient temperature;

Reference yield: 66.2%

adamantane (281-23-2) → 2-Adamantanone (700-58-3) + 1-adamantyl fluoride (768-92-3) + 1-hydroxy-3-fluoroadamante (58652-35-0) + 1-adamanthanol (768-95-6) + 1-nitroadamantane (7575-82-8)

Guidance literature:

With nitronium tetrafluoborate; In nitromethane; Mechanism; Ambient temperature; var. solvent; kinetic hydrogen isotope effect with 1,3,5,7-tetradeuterioadamantane;

upstream raw materials:

adamantane

acetic acid

benzonitrile

acetonitrile

Downstream raw materials:

1,3-dinitroadamantane

3-nitroadamantan-1-yl nitrate

Hexamethyldisiloxane

1-iodoadamantane

Refernces

• 1、 Berndt, Jan-Philipp,Erb, Frederik R.,Ochmann, Lukas,Beppler, Jaqueline,Schreiner, Peter R.. "Selective Phthalimido-N-oxyl (PINO)-Catalyzed C-H Cyanation of Adamantane Derivatives". . p. 493 - 498. Retrieved 2019/02/26.
• 2、 Klimochkin, Yu. N.,Yudashkin,Zhilkina,Ivleva,Moiseev,Oshis, Ya. F.. "One-pot synthesis of cage alcohols". . p. 971 - 976. Retrieved 2017/09/07.