Technology Process of Furan, tetrahydro-5-[(1S)-1-methoxyethyl]-3-methyl-2-(phenylthio)-,
(3S,5R)-
There total 10 articles about Furan, tetrahydro-5-[(1S)-1-methoxyethyl]-3-methyl-2-(phenylthio)-,
(3S,5R)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydride;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 2h;
DOI:10.1055/s-2005-918486
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 70 percent / DIAD; PPh3 / toluene / 16 h / 20 °C
2.1: 94 percent / KOH / ethanol / 2 h / 60 °C
3.1: 77 percent / imidazole / CH2Cl2 / 16 h / 20 °C
4.1: LDA / tetrahydrofuran / 2 h / -78 °C
4.2: tetrahydrofuran / 2 h / -78 °C
5.1: DIBAL-H / CH2Cl2 / 1 h / -78 °C
6.1: BF3*OEt2 / CH2Cl2 / 1 h / -78 °C
7.1: TBAF / tetrahydrofuran / 16 h / 20 °C
8.1: 81 percent / NaH / dimethylformamide / 2 h / 20 °C
With
1H-imidazole; potassium hydroxide; di-isopropyl azodicarboxylate; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; sodium hydride; diisobutylaluminium hydride; triphenylphosphine; lithium diisopropyl amide;
In
tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;
1.1: Mitsunobu reaction;
DOI:10.1055/s-2005-918486
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 94 percent / KOH / ethanol / 2 h / 60 °C
2.1: 77 percent / imidazole / CH2Cl2 / 16 h / 20 °C
3.1: LDA / tetrahydrofuran / 2 h / -78 °C
3.2: tetrahydrofuran / 2 h / -78 °C
4.1: DIBAL-H / CH2Cl2 / 1 h / -78 °C
5.1: BF3*OEt2 / CH2Cl2 / 1 h / -78 °C
6.1: TBAF / tetrahydrofuran / 16 h / 20 °C
7.1: 81 percent / NaH / dimethylformamide / 2 h / 20 °C
With
1H-imidazole; potassium hydroxide; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; sodium hydride; diisobutylaluminium hydride; lithium diisopropyl amide;
In
tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1055/s-2005-918486
