methyl 3-oxocyclopentane-1-carboxylate

Base Information

• Chemical Name: methyl 3-oxocyclopentane-1-carboxylate
• CAS No.: 32811-75-9
• Molecular Formula: C7H10O3
• Molecular Weight: 142.155
• Hs Code.: 2918300090
• Mol file: 32811-75-9.mol

Synonyms:Methyl3-oxocyclopentanecarboxylate;NSC 41335;

Chemical Property of methyl 3-oxocyclopentane-1-carboxylate

Chemical Property:

• Vapor Pressure: 0.2mmHg at 25°C
• Refractive Index: 1.4565 (589.3 nm 23℃)
• Boiling Point: 209.7 °C at 760 mmHg
• Flash Point: 84 °C
• PSA: 43.37000
• Density: 1.157 g/cm³
• LogP: 0.52860
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methyl3-Oxocyclopentanecarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-41-52
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 3-oxocyclopentane-1-carboxylate

There total 17 articles about methyl 3-oxocyclopentane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3-Oxo-cyclopentanecarboxylic acid (98-78-2) + methyl iodide (74-88-4) → methyl 3-oxocyclopentane-1-carboxylate (32811-75-9)

Guidance literature:

With potassium carbonate; In acetone; at 20 ℃; Inert atmosphere; Reflux;

DOI:10.1021/jacs.5b10466

Reference yield: 91.0%

methanol (67-56-1) + 3-Oxo-cyclopentanecarboxylic acid (98-78-2) → methyl 3-oxocyclopentane-1-carboxylate (32811-75-9)

Guidance literature:

With sulfuric acid; at 0 - 80 ℃; for 6h;

Reference yield: 84.0%

3-Oxo-cyclopentanecarboxylic acid (98-78-2) → methyl 3-oxocyclopentane-1-carboxylate (32811-75-9)

Guidance literature:

With sulfuric acid; In methanol; dichloromethane;

upstream raw materials:

methanol

methyl 3-oxocyclopent-1-enecarboxylate

cyclopentanone

3-Oxo-cyclopentanecarboxylic acid

Downstream raw materials:

2-oxa-bicyclo[2.2.1]heptan-3-one

(+/-)-cis-3-hydroxy-cyclopentanecarboxylic acid

(+/-)-cis-3-hydroxy-cyclopentanecarboxylic acid p-toluidide

(+/-)-cis-3-methoxy-cyclopentanecarboxylic acid p-toluidide

Refernces

• 1、 -. "MACROCYCLIC SULFONYLUREA DERIVATIVES USEFUL AS NLRP3 INHIBITORS". Page/Page column 147. . Retrieved 2021/02/26.
• 2、 -. "COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING NEURODEGENERATIVE DISORDERS". Page/Page column 77. . Retrieved 2017/03/08.