ROSEOFLAVIN

Base Information

• Chemical Name: ROSEOFLAVIN
• CAS No.: 51093-55-1
• Molecular Formula: C₁₈H₂₃N₅O₆
• Molecular Weight: 405.411
• Mol file: 51093-55-1.mol

Synonyms:Benzo[g]pteridine,riboflavin deriv.; 8-Dimethylaminoriboflavin; Roseoflavin; Roseoflavine

Chemical Property of ROSEOFLAVIN

Chemical Property:

• Melting Point: 276-278°C
• Boiling Point: °Cat760mmHg
• PKA: 9.69±0.70(Predicted)
• Flash Point: °C
• PSA: 151.91000
• Density: 1.59g/cm³
• LogP: -1.31260
• Storage Temp.: Amber Vial, -20°C Freezer
• Solubility.: DMSO (Slightly), Methanol (Slightly, Heated)

Purity/Quality:

98%,99%, ^*data from raw suppliers

Roseoflavin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Has weak antibacterial activity against some gram-positive bacteria, especially Staphylococcus aureus, Sarcina latea, Bacillus cereus, and Bacillus subtilis. Also exhibits antiriboflavin activity and inhibits the biosynthesis of riboflavin by a r An analog known to compete with Riboflavin in Lactobacillus casei. Riboflavin kinase substrate and inhibitor Roseoflavin is an antibacterial pigment isolated from Streptomyces davawensis as an anti-metabolite of riboflavin. Roseoflavin is used as a substrate to mimic riboflavin in flavin biosynthesis, but leading to the formation of inactive flavin co-factors. More recently, roseoflavin has been shown to be an important regulator of bacterial gene expression by binding to untranslated regions of RNA, so-called ribo-switching sites.

Technology Process of ROSEOFLAVIN

There total 3 articles about ROSEOFLAVIN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

8-methylamino-8-demethyl-riboflavin (62746-55-8) + S-(5′-adenosyl)-L-methionine chloride → 14N5-roseflavin (51093-55-1,58311-01-6,58311-03-8,58311-04-9)

Guidance literature:

With N,N-8-demethyl-8-amino-D-riboflavin dimethyltransferase; sodium chloride; In aq. buffer; at 25 ℃; pH=8; Kinetics; Enzymatic reaction;

DOI:10.1111/febs.13690

Reference yield:

→ 14N5-roseflavin (51093-55-1,58311-01-6,58311-03-8,58311-04-9)

Guidance literature:

Monohydrat: aus D-Ribose, 2-Dimethylamino-4-aminotoluol (VI), Violursaeure;

DOI:10.1246/bcsj.48.2877

Reference yield:

→ 7-Methyl-8-dimethylamino-10-(1'-D-arabinityl)isoalloxazin (51093-55-1,58311-01-6,58311-03-8,58311-04-9)

Guidance literature:

Monohydrat: aus Verb. VI, D-Arabinose, Violursaeure;

DOI:10.1246/bcsj.48.2877

upstream raw materials:

8-methylamino-8-demethyl-riboflavin

Downstream raw materials:

8-methylamino-8-demethyl-riboflavin

8-demethyl-8-amino-D-riboflavin

Refernces

• 1、 Kasai et al.. "". . p. 2877. Retrieved 1975.