MALONIC ACID BIS(4-NITROBENZYL) ESTER

Base Information

• Chemical Name: MALONIC ACID BIS(4-NITROBENZYL) ESTER
• CAS No.: 67245-85-6
• Molecular Formula: C17H14N2O8
• Molecular Weight: 374.307
• Mol file: 67245-85-6.mol

Synonyms:bis[(4-nitrophenyl)methyl] propanedioate;

Chemical Property of MALONIC ACID BIS(4-NITROBENZYL) ESTER

Chemical Property:

• Vapor Pressure: 6.64E-12mmHg at 25°C
• Melting Point: 89oC
• Boiling Point: 544.2°Cat760mmHg
• Flash Point: 227.9°C
• PSA: 144.24000
• Density: 1.422g/cm³
• LogP: 3.72610

Purity/Quality:

99% ^*data from raw suppliers

Bis(4-nitrobenzyl) Malonate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of MALONIC ACID BIS(4-NITROBENZYL) ESTER

There total 3 articles about MALONIC ACID BIS(4-NITROBENZYL) ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

malonic acid (141-82-2) + 1-bromomethyl-4-nitro-benzene (100-11-8) → Bis(p-nitrobenzyl) malonate (67245-85-6)

Guidance literature:

With potassium hydroxide; In diethyl ether; ethanol; water; for 1.8h; Heating;

DOI:10.1021/jo01294a044

Reference yield:

→ silicon dioxide hydrate (23382-09-4,10279-57-9,98759-73-0) + Bis(p-nitrobenzyl) malonate (67245-85-6)

Guidance literature:

Reference yield:

→ Bis(p-nitrobenzyl) malonate (67245-85-6)

Guidance literature:

upstream raw materials:

malonic acid

1-bromomethyl-4-nitro-benzene

Downstream raw materials:

bis(p-nitrobenzyl) ketomalonate

di-p-nitrobenzyl α-diazomalonate

6-Eth-(E)-ylidene-3-[2-(4-nitro-benzyloxycarbonylamino)-ethylsulfanyl]-7-oxo-1-aza-bicyclo[3.2.0]hept-3-ene-2,2-dicarboxylic acid bis-(4-nitro-benzyl) ester

6-Eth-(Z)-ylidene-3-[2-(4-nitro-benzyloxycarbonylamino)-ethylsulfanyl]-7-oxo-1-aza-bicyclo[3.2.0]hept-3-ene-2,2-dicarboxylic acid bis-(4-nitro-benzyl) ester

Refernces

• 1、 -. "2-, 5-, and 6-Substituted-1-carbadethiapen-2-em-3-carboxylic acids". . . Retrieved 2008/06/13.
• 2、 -. "3-Substituted thio-6-amido-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid". . . Retrieved 2008/06/13.