Methyl 4-(benzyloxy)-3-hydroxybenzoate

Base Information

• Chemical Name: Methyl 4-(benzyloxy)-3-hydroxybenzoate
• CAS No.: 87687-75-0
• Molecular Formula: C15H14O4
• Molecular Weight: 258.274
• Hs Code.: 2918990090
• Mol file: 87687-75-0.mol

Synonyms:Benzoic acid, 3-hydroxy-4-(phenylmethoxy)-, methyl ester

Chemical Property of Methyl 4-(benzyloxy)-3-hydroxybenzoate

Chemical Property:

• Melting Point: 129 °C
• Boiling Point: 436.7±30.0 °C(Predicted)
• PKA: 8.70±0.35(Predicted)
• PSA: 55.76000
• Density: 1.227±0.06 g/cm3(Predicted)
• LogP: 2.75780
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

Methyl4-(benzyloxy)-3-hydroxybenzoate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 4-(benzyloxy)-3-hydroxybenzoate

There total 9 articles about Methyl 4-(benzyloxy)-3-hydroxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

methyl 3-(acetyloxy)-4-(benzyloxy)benzoate → methyl 4-(benzyloxy)-3-hydroxybenzoate (87687-75-0)

Guidance literature:

With potassium carbonate; In methanol; at 20 ℃; Reflux;

Reference yield: 81.0%

3,4-dihydroxybenzoic acid methyl ester (2150-43-8) + benzyl alcohol (100-51-6,185532-71-2) → methyl 4-(benzyloxy)-3-hydroxybenzoate (87687-75-0)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; regioselective reaction;

DOI:10.1055/s-0030-1259031

Reference yield: 78.0%

3,4-dihydroxybenzoic acid methyl ester (2150-43-8) + benzyl bromide (100-39-0) → methyl 4-(benzyloxy)-3-hydroxybenzoate (87687-75-0)

Guidance literature:

With hydrogen; potassium carbonate; In acetonitrile; at 80 ℃; for 12h;

upstream raw materials:

3,4-dihydroxybenzoic acid methyl ester

benzyl chloride

benzyl bromide

3,4-Dihydroxybenzoic acid

Downstream raw materials:

C₂₃H₂₉ClO₇

dimethyl 4,4'-bis(benzyloxy)-3,3'-[oxy(tetra(ethyleneoxy))]dibenzoate

3-allyloxy-4-benzyloxy-benzoic acid methyl ester

Refernces

• 1、 -. "NOVEL ISOINDOLINE DERIVATIVE, AND PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF". Paragraph 0126; 0128; 0130. . Retrieved 2020/01/22.
• 2、 Kwan, Chak-Shing,Wang, Tao,Li, Min,Chan, Albert S. C.,Cai, Zongwei,Leung, Ken Cham-Fai. "Type III-C rotaxane dendrimers: Synthesis, dual size modulation and: In vivo evaluation". supporting information. p. 13426 - 13429. Retrieved 2019/11/16.