2-naphthylisothiocyanate

Base Information

• Chemical Name: 2-naphthylisothiocyanate
• CAS No.: 1636-33-5
• Molecular Formula: C11H7 N S
• Molecular Weight: 185.249
• Hs Code.: 2930909090
• Mol file: 1636-33-5.mol

Synonyms:Isothiocyanicacid, 2-naphthyl ester (6CI,7CI,8CI); 2-Isothiocyanatonaphthalene; 2-Naphthylisothiocyanate; NSC 93938; b-Naphthyl isothiocyanate

Chemical Property of 2-naphthylisothiocyanate

Chemical Property:

• Vapor Pressure: 0.000182mmHg at 25°C
• Melting Point: 59 °C
• Refractive Index: 1.5500 (estimate)
• Boiling Point: 339.3°Cat760mmHg
• Flash Point: 167.2°C
• PSA: 44.45000
• Density: 1.11g/cm³
• LogP: 3.57410
• Water Solubility.: 6.669mg/L(25 oC)

Purity/Quality:

99% ^*data from raw suppliers

2-Isothiocyanatonaphthalene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-naphthylisothiocyanate

There total 24 articles about 2-naphthylisothiocyanate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

thiophosgene (463-71-8) + naphthalen-2-ylamine (91-59-8) → 2-naphthyl isothiocyanate (1636-33-5)

Guidance literature:

at 0 - 20 ℃; for 0.666667h;

Reference yield: 87.0%

naphthalen-2-ylamine (91-59-8) + (2-bromo-2,2-difluoro-acetyl)oxysodium → 2-naphthyl isothiocyanate (1636-33-5)

Guidance literature:

With sulfur; potassium phosphate; copper(l) iodide; In acetonitrile; at 100 ℃; for 12h; Reagent/catalyst; Solvent; Temperature; Schlenk technique;

DOI:10.1039/c8cc09190k

Reference yield: 77.0%

carbon disulfide (75-15-0,12122-00-8) + N-(2-naphthyl)-2,2,2-trifluoroacetamide (398-48-1) → 2-naphthyl isothiocyanate (1636-33-5)

Guidance literature:

With sodium hydroxide; potassium carbonate; In acetonitrile; at 25 ℃; for 1.5h;

DOI:10.1055/s-1991-26629

upstream raw materials:

N,N'-di(2-naphthyl)thiourea

carbon disulfide

di-[2]naphthyl-carbodiimide

1-naphthalen-2-yl-3-phenyl-thiourea

Downstream raw materials:

2-Benzenesulfonyl-2-cyano-N-naphthalen-2-yl-thioacetamide

N-(5-methylisoxazol-3-yl)-4-(3-naphthalen-2-ylthioureido)benzenesulfonamide

C₂₃H₁₈N₄

C₂₁H₁₉N₅O

Refernces

• 1、 Pawar, Chandrakant D.,Chavan, Sadhana L.,Pawar, Umakant D.,Pansare, Dattatraya N.,Deshmukh, Santosh V.,Shinde, Devanand B.. "Synthesis, anti-proliferative activity, SAR, and kinase inhibition studies of thiazol-2-yl- substituted sulfonamide derivatives". . p. 257 - 264. Retrieved 2018/11/27.
• 2、 -. "Isothiocyanate synthesized by three components and preparation method of isothiocyanate". Paragraph 0033; 0056; 0057-0072. . Retrieved 2019/04/26.