NAPROPAMIDE

Base Information

• Chemical Name: NAPROPAMIDE
• CAS No.: 41643-36-1
• Molecular Formula: C17H21NO2
• Molecular Weight: 271.35414
• Mol file: 41643-36-1.mol

Synonyms:L-N,N-diethyl-2-(α-naphthoxy)propionamide;L-(-)-N,N-diethyl-2-(α-naphthoxy)propionamide;L-napropamide;(S)-N,N-diethyl-2-(1-naphthalenyloxy)propanamide;(S)-N,N-diethyl-2-(α-naphthoxy)propionamide;

Chemical Property of NAPROPAMIDE

Chemical Property:

• PSA: 29.54000
• LogP: 3.47550

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of NAPROPAMIDE

There total 2 articles about NAPROPAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

α-naphthol (90-15-3) + (L)-(+)-N,N-diethyl-2-chloropropionamide → (R)-napropamide (41643-35-0) + (S)-napropamide (41643-36-1)

Guidance literature:

With sodium hydroxide; In water; toluene; at 55 - 95 ℃; for 6 - 7h; Product distribution / selectivity; Heating / reflux;

Reference yield:

Napropamide (15299-99-7) → (R)-napropamide (41643-35-0) + (S)-napropamide (41643-36-1)

Guidance literature:

With Chiralpak IC; In hexane; isopropyl alcohol; at 15 ℃; Resolution of racemate;

DOI:10.1002/chir.22277

upstream raw materials:

Napropamide

α-naphthol

Refernces

• 1、 Huang, Junwei,Chen, Dian,Cheng, Xiaokun,Liu, Guiping,Wang, Guoxiang,Jiang, Jiandong. "Enantioselective Catabolism of Napropamide Chiral Enantiomers in Sphingobium sp. A1 and B2". . p. 6819 - 6827. Retrieved 2019/06/24.
• 2、 Qi, Yanli,Liu, Donghui,Sun, Mingjing,Di, Shanshan,Wang, Peng,Zhou, Zhiqiang. "The chiral separation and enantioselective degradation of the chiral herbicide napropamide". . p. 108 - 113. Retrieved 2014/03/21.