3-Methoxyphenylhydrazine hydrochloride

Base Information

• Chemical Name: 3-Methoxyphenylhydrazine hydrochloride
• CAS No.: 39232-91-2
• Molecular Formula: C7H10N2O^.HCl
• Molecular Weight: 174.63
• Hs Code.: 29280000
• European Community (EC) Number: 254-368-4
• NSC Number: 155337
• DSSTox Substance ID: DTXSID10960005
• Mol file: 39232-91-2.mol

Synonyms:39232-91-2;3-Methoxyphenylhydrazine hydrochloride;(3-methoxyphenyl)hydrazine Hydrochloride;3-Methoxyphenylhydrazine HCl;3-Methoxyphenylhydrazine, HCl;Hydrazine, (3-methoxyphenyl)-, monohydrochloride;(3-methoxyphenyl)hydrazine;hydrochloride;MFCD00044416;EINECS 254-368-4;3-methoxy-phenylhydrazine hydrochloride;N(N)c1cccc(OC)c1;SCHEMBL7305;3-methoxyphenyl-hydrazine HCl;DTXSID10960005;GMXFZBZOVZOYNQ-UHFFFAOYSA-N;3-methoxyphenylhydrazin hydrochloride;m-Methoxyphenylhydrazine hydrochloride;NSC155337;3-methyoxyphenylhydrazine hydrochloride;AKOS005259075;3-Methoxyphenyl hydrazine hydrochloride;CS-W017475;NSC-155337;AS-18333;SY031446;(3-methoxy-phenyl) hydrazine hydrochloride;(3-Methoxy-phenyl)-hydrazine hydrochloride;3-Methoxylphenylhydrazine hydrochloride salt;3-Methoxyphenylhydrazine, hydrochloride 95%;A6573;AM20061197;FT-0600567;EN300-18896;3-methoxyphenylhydrazine hydrochloric acid salt;I10071;(3-Methoxyphenyl)hydrazine--hydrogen chloride (1/1);Z94599902;(3-Methoxy-phenyl)-hydrazine;(3-Methoxyphenyl)hydrazine hydrochloride

Chemical Property of 3-Methoxyphenylhydrazine hydrochloride

Chemical Property:

• Appearance/Colour: pinkish to pink-brownish powder
• Vapor Pressure: 0.00515mmHg at 25°C
• Melting Point: 142°C (dec.)
• Boiling Point: 275.3 °C at 760 mmHg
• Flash Point: 120.3 °C
• PSA: 47.28000
• Density: 1.15g/cm3
• LogP: 2.55610
• Storage Temp.: Keep Cold
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 174.0559907
• Heavy Atom Count: 11
• Complexity: 97.6

Purity/Quality:

98%, ^*data from raw suppliers

3-Methoxyphenylhydrazine HCl ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 20/21/22-36/37/38-22
• Safety Statements: 26-36/37/39-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC(=C1)NN.Cl
• Uses: (3-Methoxyphenyl)hydrazine Hydrochloride can be used to treat brain disorders.

Technology Process of 3-Methoxyphenylhydrazine hydrochloride

There total 5 articles about 3-Methoxyphenylhydrazine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.8%

C7H8N2O*(x)ClH → m-methoxyphenylhydrazine hydrochloride (39232-91-2)

Guidance literature:

C₇H₈N₂O*(x)ClH; With palladium on activated charcoal; hydrogen; at 90 ℃; for 6h; under 30003 Torr;

With hydrogenchloride; In water; at 100 ℃; for 2h;

Reference yield: 82.0%

3-methoxy-1-iodobenzene (766-85-8) → m-methoxyphenylhydrazine hydrochloride (39232-91-2)

Guidance literature:

3-methoxy-1-iodobenzene; With potassium phosphate; copper(l) iodide; N,N′-bis(2,6-dimethylphenyl)oxalamide; cetyltrimethylammonim bromide; In water; at 80 ℃; for 0.25h; Schlenk technique; Inert atmosphere; Sealed tube;

With hydrazine hydrate; In water; at 80 ℃; Inert atmosphere; Schlenk technique; Sealed tube;

With hydrogenchloride; In water; pH=3 - 4; Inert atmosphere; Schlenk technique; Sealed tube;

DOI:10.1002/cjoc.201800326

Reference yield: 78.0%

3-methoxyphenyl bromide (2398-37-0) → m-methoxyphenylhydrazine hydrochloride (39232-91-2)

Guidance literature:

3-methoxyphenyl bromide; With potassium phosphate; copper(l) iodide; N,N′-bis(2,6-dimethylphenyl)oxalamide; cetyltrimethylammonim bromide; In water; at 80 ℃; for 0.25h; Schlenk technique; Inert atmosphere; Sealed tube;

With hydrazine hydrate; In water; at 80 ℃; Inert atmosphere; Schlenk technique; Sealed tube;

With hydrogenchloride; In water; pH=3 - 4; Inert atmosphere; Schlenk technique; Sealed tube;

DOI:10.1002/cjoc.201800326

upstream raw materials:

m-Anisidine

3-methoxyphenyl bromide

3-methoxy-1-iodobenzene

Downstream raw materials:

4-[1-(3-methoxy-phenyl)-3,5-dimethyl-1H-pyrazol-4-ylazo]-N-thiazol-2-yl-benzenesulfonamide

6-methoxy-3-(4-methoxyphenyl)-2-methyl-1H-indole

2-Ethyl-6-methoxy-3-(3-methoxyphenyl)-indole

2-ethyl-6-methoxy-3-(4-methoxyphenyl)indole

Refernces

• 1、 -. "AZEPINO-INDOLES AND OTHER HETEROCYCLES FOR TREATING BRAIN DISORDERS". Paragraph 0223. . Retrieved 2020/09/12.
• 2、 Kumar, Siripuram Vijay,Ma, Dawei. "Synthesis of Aryl Hydrazines via CuI/BMPO Catalyzed Cross-Coupling of Aryl Halides with Hydrazine Hydrate in Water". supporting information. p. 1003 - 1006. Retrieved 2018/09/20.