1-[(6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)carbonyl]piperidine

Base Information

• Chemical Name: 1-[(6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)carbonyl]piperidine
• CAS No.: 878208-57-2
• Molecular Formula: C15H18FNO2
• Molecular Weight: 263.30700
• Mol file: 878208-57-2.mol

Synonyms:6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid piperidine amide;

Chemical Property of 1-[(6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)carbonyl]piperidine

Chemical Property:

• Melting Point: 97-100°C
• PSA: 29.54000
• LogP: 2.46970
• Storage Temp.: -20°C Freezer
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

95% ^*data from raw suppliers

1-[(6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)carbonyl]piperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-[(6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)carbonyl]piperidine

There total 2 articles about 1-[(6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)carbonyl]piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid (99199-60-7,129050-20-0) + piperidine (110-89-4) → 6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid piperidine amide (878208-57-2)

Guidance literature:

6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid; With chloroformic acid ethyl ester; triethylamine; In dichloromethane; at 0 - 5 ℃; for 1.5 - 2.25h;

piperidine; In dichloromethane; at 0 - 5 ℃; for 2 - 2.25h; Product distribution / selectivity;

Reference yield:

nebulic acid chloride (850896-51-4,155427-30-8) + piperidine (110-89-4) → 6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid piperidine amide (878208-57-2)

Guidance literature:

In toluene; at 20 ℃; for 0.5h; Product distribution / selectivity;

Reference yield:

6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid piperidine amide (878208-57-2) → 6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxaldehyde (409346-73-2)

Guidance literature:

6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid piperidine amide; With sodium bis(2-methoxyethoxy)aluminium dihydride; In toluene; at 10 - 15 ℃;

With methanol; In toluene;

upstream raw materials:

nebulic acid chloride

piperidine

6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid

Downstream raw materials:

6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxaldehyde

Refernces