(3R,5R)-7-[(1S,2R,3S,8S,8aR)-3-hydroxy-2-methyl-8-[(2S)-2-methylbutano yl]oxy-1,2,3,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxy-heptanoic acid

Base Information

• Chemical Name: (3R,5R)-7-[(1S,2R,3S,8S,8aR)-3-hydroxy-2-methyl-8-[(2S)-2-methylbutano yl]oxy-1,2,3,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxy-heptanoic acid
• CAS No.: 81131-74-0
• Molecular Formula: C₂₃H₃₆O₇
• Molecular Weight: 424.535
• Mol file: 81131-74-0.mol

Synonyms:

Chemical Property of (3R,5R)-7-[(1S,2R,3S,8S,8aR)-3-hydroxy-2-methyl-8-[(2S)-2-methylbutano yl]oxy-1,2,3,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxy-heptanoic acid

Chemical Property:

• Vapor Pressure: 4.3E-19mmHg at 25°C
• Boiling Point: 640.3°Cat760mmHg
• Flash Point: 215.5°C
• PSA: 124.29000
• Density: 1.21g/cm³
• LogP: 2.44040

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3R,5R)-7-[(1S,2R,3S,8S,8aR)-3-hydroxy-2-methyl-8-[(2S)-2-methylbutano yl]oxy-1,2,3,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxy-heptanoic acid

There total 7 articles about (3R,5R)-7-[(1S,2R,3S,8S,8aR)-3-hydroxy-2-methyl-8-[(2S)-2-methylbutano yl]oxy-1,2,3,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxy-heptanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.4%

mevastatin (73573-88-3,58948-09-7) → pravastatin (81093-37-0,81131-74-0,250737-12-3)

Guidance literature:

Reference yield:

pravastatin sodium salt (81131-70-6,81176-41-2,124917-23-3) → pravastatin (81093-37-0,81131-74-0,250737-12-3)

Guidance literature:

With hydrogenchloride; In water; pH=4.0;

Reference yield:

Compactin sodium salt → pravastatin (81093-37-0,81131-74-0,250737-12-3)

Guidance literature:

With carbenicillin; isopropyl β-D-thiogalactopyranoside; glycerol; at 28 ℃; for 24h; pH=7.4; aq. phosphate buffer;

DOI:10.1271/bbb.80627

upstream raw materials:

3,5-bis-epi-compactin

mevastatin

pravastatin sodium salt

Downstream raw materials:

pravastatin sodium salt

(S)-2-Methyl-butyric acid (1S,3R,4aS,7S,8S,8aS)-8-(2-{(4R,6S)-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethyl)-3-hydroxy-7-methyl-decahydro-naphthalen-1-yl ester

(S)-2-Methyl-butyric acid (1S,4aS,7S,8S,8aS)-8-(2-{(4R,6S)-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethyl)-7-methyl-3-oxo-decahydro-naphthalen-1-yl ester

(S)-2-Methyl-butyric acid (1S,3R,4aS,7S,8S,8aS)-8-[(3R,5S)-7-(tert-butyl-diphenyl-silanyloxy)-3,5-dihydroxy-heptyl]-3-hydroxy-7-methyl-decahydro-naphthalen-1-yl ester

Refernces

• 1、 -. "Fermentation Medias and Processes Thereof". Page/Page column. . Retrieved 2014/05/25.
• 2、 -. "Methods for predicting the response to statins". . . Retrieved 2011/10/13.