CRF (OVINE)

Base Information

• Chemical Name: CRF (OVINE)
• CAS No.: 9015-71-8
• Molecular Formula: C205H339N59O63S1
• Molecular Weight: 4670.31
• Mol file: 9015-71-8.mol

Synonyms:ACTH-releasingfactor; ACTH-releasing hormone; CRF; CRF (hormone); Corticoliberin; Corticotropin-releasingactivity; Corticotropin-releasing hormone

Chemical Property of CRF (OVINE)

Chemical Property:

• Storage Temp.: −20°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Corticotropin Releasing Hormone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Biological functions: CRH stimulates the synthesis and processing of proopiomelanocortin (POMC) to generate ACTH in the anterior pituitary. CRH also stimulates ACTH release. ACTH is secreted into the systemic circulation, reaches the adrenal cortex, and stimulates the synthesis and release of glucocorticoids. CRH also acts as a neuromodulator in the brain. CRH in the brain regulates the endocrine system, autonomic nervous system, and immune system in response to stress. In addition to the stress response, CRH is involved in multiple physiological functions such as suppression of food intake, regulation of body temperature, growth, metabolism, metamorphosis, reproduction, and diuresis. In mammals, CRH inhibits the female reproductive axis by suppressing gonadotropinreleasing hormone (GnRH) secretion. CRH2 stimulates TSHβ expression and shows a lower potency in inducing ACTH secretion in vitro in the chicken.
• Description: CRH is a key activator of the hypothalamo-pituitaryadrenal (HPA) axis in response to internal or external stresses by stimulating adrenocorticotropic hormone (ACTH) secretion from the pituitary.
• Clinical Use: Clinical implications Increased CRH production has been suggested to be associated with Alzheimer’s disease and depression. CRH deficiency has been observed to induce hypoglycemia and hepatitis. CRH has been used in the diagnosis of ACTH-dependent Cushing’s syndrome and Addison’s disease. Use for diagnosis and treatment CRHR1 antagonists Pexacerfont and Antalarmin are under clinical trial for the treatment of generalized anxiety disorder as well as depression and other mental disorders, respectively