Isoarecoline

Base Information

• Chemical Name: Isoarecoline
• CAS No.: 59097-06-2
• Molecular Formula: C8H13NO2
• Molecular Weight: 155.197
• Hs Code.: 2933399990
• Mol file: 59097-06-2.mol

Synonyms:methyl 1,2,3,6-tetrahydro-1-methylisonicotinate;1-methyl-1,2,3,6-tetrahydro-pyridine-4-carboxylic acid methyl ester;1-Methyl-1,2,3,6-tetrahydro-pyridin-4-carbonsaeure-methylester;

Chemical Property of Isoarecoline

Chemical Property:

• PSA: 29.54000
• LogP: 0.35920

Purity/Quality:

99% ^*data from raw suppliers

methyl1-methyl-1,2,3,6-tetrahydropyridine-4-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Isoarecoline

There total 1 articles about Isoarecoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(methoxycarbonyl)-1-methylpyridinium iodide (7630-02-6) → Isonicotinic acid (59097-06-2) + 1-methyl-piperidine-4-carboxylic acid methyl ester (1690-75-1)

Guidance literature:

With methanol; platinum; Hydrogenation;

DOI:10.1021/jo01364a026

Reference yield: 84.2%

piperidine (110-89-4) + Isonicotinic acid (59097-06-2) + thiophenol (108-98-5) → methyl 1-methyl-3-(phenylthio)-isonipecotinate (80369-46-6)

Guidance literature:

With sodium hydroxide; In methanol; water;

Reference yield: 79.0%

Isonicotinic acid (59097-06-2) + N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine (93102-05-7) → methyl-2-benzyl-5-methyloctahydro-7aH-pyrrolo[3,4-c]pyridine-7a-carboxylate (1807941-67-8)

Guidance literature:

With lithium fluoride; In acetonitrile; at 80 ℃; for 12h;

DOI:10.1021/acs.joc.1c01327

upstream raw materials:

4-(methoxycarbonyl)-1-methylpyridinium iodide

Downstream raw materials:

(1,2,3,6-tetrahydro-1-methylpyridin-4-yl)diphenylmethanol

(1S,3S,4R)-3-(4-Chloro-phenylsulfanyl)-1-methyl-piperidine-4-carboxylic acid methyl ester

methyl 1-methyl-3-(phenylthio)-isonipecotinate

C₁₅H₂₆N₂O₄