N-(4-CHLOROPHENYL)SUCCINIMIDE

Base Information

• Chemical Name: N-(4-CHLOROPHENYL)SUCCINIMIDE
• CAS No.: 6943-00-6
• Molecular Formula: C10H8ClNO2
• Molecular Weight: 209.632
• Mol file: 6943-00-6.mol

Synonyms:2,5-Pyrrolidinedione, 1-(4-chlorophenyl)-;

Chemical Property of N-(4-CHLOROPHENYL)SUCCINIMIDE

Chemical Property:

• Vapor Pressure: 2.69E-08mmHg at 25°C
• Boiling Point: 450.2°Cat760mmHg
• Flash Point: 226.1°C
• PSA: 37.38000
• Density: 1.407g/cm³
• LogP: 2.05840

Purity/Quality:

99% ^*data from raw suppliers

2,5-PYRROLIDINEDIONE-1-(4-CHLOROPHENYL)-(9CI) 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(4-CHLOROPHENYL)SUCCINIMIDE

There total 15 articles about N-(4-CHLOROPHENYL)SUCCINIMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

succinic acid anhydride (108-30-5) + 4-chloro-aniline (106-47-8) → 1-(4-chlorophenyl)pyrrolidine-2,5-dione (6943-00-6)

Guidance literature:

In decaethylene glycol; at 120 ℃; for 6h;

DOI:10.1080/00397910802474966

Reference yield: 93.0%

succinic acid (110-15-6) + 4-chloro-aniline (106-47-8) → 1-(4-chlorophenyl)pyrrolidine-2,5-dione (6943-00-6)

Guidance literature:

With polyphosphoric acid; at 80 ℃; for 12h;

DOI:10.1016/j.tetlet.2014.03.021

Reference yield: 77.0%

succinic acid anhydride (108-30-5) + 4-chlorobenzonitrile (100-00-5) → 1-(4-chlorophenyl)pyrrolidine-2,5-dione (6943-00-6)

Guidance literature:

4-chlorobenzonitrile; With trichlorosilane; triethylamine; In acetonitrile; at 0 - 25 ℃; for 1h;

succinic acid anhydride; In acetonitrile; for 24h; chemoselective reaction;

DOI:10.1039/c9ra10758d

upstream raw materials:

succinic acid anhydride

4-chloro-aniline

3-chloro-1-(4-chlorophenyl)succinimide

N-4-chlorophenyl-maleamic acid

Downstream raw materials:

1-(4-chloro-phenyl)-5-hydroxy-pyrrolidin-2-one

1-(4-chloro-phenyl)-3-morpholin-4-yl-pyrrole-2,5-dione

Refernces

• 1、 Ciprés-Flores, Fabiola J.,Farfán-García, Eunice D.,Andrade-Jorge, Erik,Cuevas-Hernández, Roberto I.,Tamay-Cach, Feliciano,Martínez-Archundia, Marlet,Trujillo-Ferrara, José G.,Soriano-Ursúa, Marvin A.. "Identification of two arylimides as cholinesterase inhibitors and testing of propranolol addition on impaired rat memory". . p. 256 - 266. Retrieved 2019/12/30.
• 2、 Feng, Kaibo,Kohrt, Jeffrey T.,Oderinde, Martins S.,Quevedo, Raundi E.,Reilly, Usa,White, M. Christina. "Late-stage oxidative C(sp 3)–H methylation". . p. 621 - 627. Retrieved 2020/05/04.