1-Ethyl-1-phenylhydrazine

Base Information

• Chemical Name: 1-Ethyl-1-phenylhydrazine
• CAS No.: 644-21-3
• Molecular Formula: C8H12 N2
• Molecular Weight: 136.197
• Hs Code.: 2928000090
• European Community (EC) Number: 680-005-8
• DSSTox Substance ID: DTXSID80214648
• Nikkaji Number: J46.517H
• Wikidata: Q63398095
• Mol file: 644-21-3.mol

Synonyms:1-Ethyl-1-phenylhydrazine;644-21-3;Hydrazine, 1-ethyl-1-phenyl-;N-Ethyl-N-phenylhydrazine;CCRIS 4560;BRN 2689935;3-15-00-00074 (Beilstein Handbook Reference);Aethylphenylhydrazin;1-Phenyl-1-ethylhydrazine;1-ethyl-1-phenyl-hydrazine;SCHEMBL2126003;DTXSID80214648;MFCD00031413;AKOS003582859;SB75394;AS-47607;LS-76796;CS-0207014;E0551;FT-0632736;F14622;A834748;Q63398095

Chemical Property of 1-Ethyl-1-phenylhydrazine

Chemical Property:

• Vapor Pressure: 0.0459mmHg at 25°C
• Refractive Index: 1.5670-1.5710
• Boiling Point: 237°C at 760 mmHg
• PKA: 5.37±0.10(Predicted)
• Flash Point: 99.4°C
• PSA: 29.26000
• Density: 1.02
• LogP: 2.08690
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 136.100048391
• Heavy Atom Count: 10
• Complexity: 87.3

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-Ethyl-1-phenylhydrazine ^*data from reagent suppliers

Safty Information:

• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCN(C1=CC=CC=C1)N

Technology Process of 1-Ethyl-1-phenylhydrazine

There total 19 articles about 1-Ethyl-1-phenylhydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.1%

N-ethyl-N-nitrosoaniline (612-64-6) → 1-ethyl-1-phenylhydrazine (644-21-3)

Guidance literature:

N-ethyl-N-nitrosoaniline; With acetic acid; zinc; In water; at 10 - 80 ℃;

With sodium hydroxide; In water; pH=12;

Reference yield: 32.0%

ethyl iodide (75-03-6) + phenylhydrazine (100-63-0) → 1-ethyl-1-phenylhydrazine (644-21-3)

Guidance literature:

With sodium hydroxide; tetrabutyl-ammonium chloride; at 25 ℃; for 15h;

Reference yield:

3-amino-1-ethyl-4,5-dihydro-1-phenyl-1H-pyrazolium iodide (106087-09-6) → 1-ethyl-1-phenylhydrazine (644-21-3) + 3-hydroxypropanoic acid sodium salt (6487-38-3) + N-ethyl-N-phenylamine (103-69-5)

Guidance literature:

With sodium hydroxide; In water; for 2h; Yield given. Yields of byproduct given; Heating;

upstream raw materials:

ethyl bromide

phenyl-hydrazine; sodium-compound

N-ethyl-N-nitrosoaniline

diethylzinc

Downstream raw materials:

2,4,6-triphenyl-1,3,5-triazine

4,5-Dimethyl-2-phenyl-2H-1,2,3-triazole

1-ethyl-2-phenyl-1H-indole

ammonia

Refernces

• 1、 Zhang, Lei,Chen, Junyu,Chen, Xiahe,Zheng, Xiangyun,Zhou, Jian,Zhong, Tianshuo,Chen, Zhiwei,Yang, Yun-Fang,Jiang, Xinpeng,She, Yuan-Bin,Yu, Chuanming. "Rh(iii)-catalyzed, hydrazine-directed C-H functionalization with 1-alkynylcyclobutanols: A new strategy for 1: H -indazoles". supporting information. p. 7415 - 7418. Retrieved 2020/07/15.
• 2、 Zhou, Shuguang,Wang, Jinhu,Zhang, Feifei,Song, Chao,Zhu, Jin. "A Versatile, Traceless C-H Activation-Based Approach for the Synthesis of Heterocycles". supporting information. p. 2427 - 2430. Retrieved 2016/06/09.