P-ANISALDEHYDE DIMETHYL ACETAL

Base Information

• Chemical Name: P-ANISALDEHYDE DIMETHYL ACETAL
• CAS No.: 2186-92-7
• Molecular Formula: C10H14O3
• Molecular Weight: 182.219
• Hs Code.: 29110000
• European Community (EC) Number: 218-577-4
• UNII: XTE77A5ET4
• DSSTox Substance ID: DTXSID3062239
• Nikkaji Number: J183.678A
• Wikidata: Q27293986
• Mol file: 2186-92-7.mol

Synonyms:Toluene, p,a,a-trimethoxy- (5CI);p-Anisaldehyde, dimethyl acetal(7CI,8CI);(p-Methoxyphenyl)dimethoxymethane;1-(Dimethoxymethyl)-4-methoxybenzene;4-Anisaldehyde dimethyl acetal;4-Methoxybenzaldehyde dimethyl acetal;Anisaldehyde dimethyl acetal;Anisic aldehyde dimethyl acetal;Dimethoxy(4-methoxyphenyl)methane;p-(Dimethoxymethyl)anisole;p-Methoxybenzaldehyde dimethyl acetal;

Chemical Property of P-ANISALDEHYDE DIMETHYL ACETAL

Chemical Property:

• Appearance/Colour: clear colorless to light yellow liquid
• Vapor Pressure: 0.0171mmHg at 25°C
• Refractive Index: n20/D 1.505
• Boiling Point: 224.9 °C at 760 mmHg
• Flash Point: 72.8 °C
• PSA: 27.69000
• Density: 1.033 g/cm³
• LogP: 1.98660
• Storage Temp.: 2-8°C
• Solubility.: H2O: soluble
• Water Solubility.: Miscible with alcohol and many organic solvents. Slightly miscible with water.
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 182.094294304
• Heavy Atom Count: 13
• Complexity: 126

Purity/Quality:

99.0% ^*data from raw suppliers

Anisaldehyde dimethyl acetal ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(OC)OC
• Uses: 4-Methoxybenzaldehyde dimethyl acetal is used as a precursor to 1-methoxy-1-(4-methoxyphenyl)hept-2-yne, 2,5-dioxopyrrolidin-1-yl-3-((4R)-2-(4-methoxyphenyl)-5,5-dimethyl-1,3-dioxane-4-carboxamido)propanoate and 1-(p-anisyl)-2-(2-methoxyethyl)-3-phenylindene. Further, it acts as a protecting group reagent for diols, especially in carbohydrates. It is also used as a flavor essence in sunflower, cyclamen and in jasmine. In addition to this, it is involved in allylation reactions with allyltrimethylsilane catalyzed by Iron(III) chloride.

Technology Process of P-ANISALDEHYDE DIMETHYL ACETAL

There total 31 articles about P-ANISALDEHYDE DIMETHYL ACETAL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methanol (67-56-1) + 4-methoxy-benzaldehyde (123-11-5) → p-Anisaldehyde dimethyl acetal (2186-92-7)

Guidance literature:

mesoporous aluminosilicate; at 50 ℃; for 1h;

DOI:10.1016/j.tetlet.2007.05.022

Reference yield: 98.0%

trifluoroacetic acid-methyl ester (431-47-0) + sodium methylate (124-41-4) + 4-methoxy-benzaldehyde (123-11-5) → p-Anisaldehyde dimethyl acetal (2186-92-7)

Guidance literature:

In methanol; at 20 ℃; Inert atmosphere;

DOI:10.1039/c8ob00017d

Reference yield: 90.0%

dimethylsulfite (616-42-2) + 4-methoxy-benzaldehyde (123-11-5) → p-Anisaldehyde dimethyl acetal (2186-92-7)

Guidance literature:

With hydrogenchloride; In methanol;

DOI:10.1021/jm00396a012

upstream raw materials:

methanol

4-methoxy-benzaldehyde

trimethyl orthoformate

N,N-bis(4-methoxybenzylidene)hydrazine

Downstream raw materials:

1-(chloro-methoxy-methyl)-4-methoxy-benzene

3-methoxy-3-(4-methoxyphenyl)-1-phenyl-propan-1-one

benzyl 4,6-O-(4-methoxybenzylidene)-β-D-glucopyranoside

2-(trimethylsilyl)ethyl 4-O-(4,6-O-p-methoxybenzylidene-β-D-galactopyranosyl)-β-D-glucopyranoside

Refernces

• 1、 Bouzek, Karel,Jiricny, Vladimir,Kodym, Roman,Kristal, Jiri,Bystron, Tomas. "Microstructured reactor for electroorganic synthesis". . p. 8172 - 8181. Retrieved 2010.
• 2、 Porwanski,Salanski,Descotes,Bouchu,Queneau. "Selective synthesis of 4,6-O-alkenylidene and -benzylidene acetals from unprotected sucrose by lanthanide(III) resin-catalyzed transacetalization". . p. 525 - 528. Retrieved 2000.
• 3、 Yu, Congjun,?zkaya, Bünyamin,Patureau, Frederic W.. "Electro-Oxidative Selective Esterification of Methylarenes and Benzaldehydes". supporting information. p. 3682 - 3687. Retrieved 2021/02/01.
• 4、 Rayes, Ali,Herrera, Raquel P,Moncer, Manel,Ara, Irene,Calestani, Gianluca,Ayed, Brahim,Mezzadri, Francesco. "Synthesis, structural determination and catalytic study of a new 2-D chloro-substituted zinc phosphate, (C8N2H20)[ZnCl(PO3(OH))]2". . . Retrieved 2019/11/03.