2-Anilino-2-phenylacetic acid

Base Information

• Chemical Name: 2-Anilino-2-phenylacetic acid
• CAS No.: 3684-12-6
• Molecular Formula: C14H13NO2
• Molecular Weight: 227.263
• Hs Code.: 2922499990
• European Community (EC) Number: 640-443-2
• NSC Number: 3335
• DSSTox Substance ID: DTXSID001346520
• Nikkaji Number: J49.230B
• Mol file: 3684-12-6.mol

Synonyms:3684-12-6;anilino(phenyl)acetic acid;2-Anilino-2-phenylacetic acid;2-phenyl-2-(phenylamino)acetic acid;phenyl(phenylamino)acetic acid;N,2-Diphenylglycine;GLYCINE, N,2-DIPHENYL-;N,alpha-Diphenylglycine;MFCD01724775;Phenyl-phenylamino-acetic acid;NSC 3335;Benzeneacetic acid, alpha-(phenylamino)-;AI3-18676;N-Phenyl-2-phenylglycine;NSC3335;WLN: QVYR&MR;phenylaminophenylacetic acid;phenyl (phenylamino)acetic acid;SCHEMBL2483521;YSZC1940;DTXSID001346520;2-phenyl-2-(phenylamino)aceticacid;NSC-3335;alpha-(Phenylamino)benzeneacetic acid;AKOS005257367;PS-3042;SB79632;LS-72602;Benzeneacetic acid, .alpha.-(phenylamino)-;E73910;Phenyl(phenylamino)acetic acid (Ph-DL-Phg-OH);N,-Diphenylglycine

Chemical Property of 2-Anilino-2-phenylacetic acid

Chemical Property:

• Vapor Pressure: 1.54E-07mmHg at 25°C
• Boiling Point: 412.3 °C at 760 mmHg
• Flash Point: 203.2 °C
• PSA: 49.33000
• Density: 1.252 g/cm³
• LogP: 2.99740
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 227.094628657
• Heavy Atom Count: 17
• Complexity: 243

Purity/Quality:

98%min ^*data from raw suppliers

Phenyl(phenylamino)acetic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(C(=O)O)NC2=CC=CC=C2

Technology Process of 2-Anilino-2-phenylacetic acid

There total 26 articles about 2-Anilino-2-phenylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-bromophenylacetic acid (4870-65-9,31302-84-8) + aniline (62-53-3) → 2-phenyl-2-(phenylamino)acetic acid (3684-12-6)

Guidance literature:

2-bromophenylacetic acid; aniline; at 120 ℃; for 0.0833333h; Microwave irradiation;

With sodium carbonate; In dichloromethane; water;

With hydrogenchloride; In water;

Reference yield: 97.0%

2-bromophenylacetic acid (4870-65-9,31302-84-8) + dichloromethane (DCM) → 2-phenyl-2-(phenylamino)acetic acid (3684-12-6)

Guidance literature:

With sodium carbonate; In aniline;

Reference yield: 87.0%

carbon dioxide (124-38-9,18923-20-1) + benzylidene phenylamine (538-51-2) → 2-phenyl-2-(phenylamino)acetic acid (3684-12-6)

Guidance literature:

With tetrabutylammomium bromide; In N,N-dimethyl-formamide; at 24 ℃; under 760 Torr; electrolysis in diaphragmless cell, graphite cathode, Al anode;

upstream raw materials:

α-anilino-α-phenylacetamide

2-bromophenylacetic acid

aniline

Chloro-phenyl-acetic acid

Downstream raw materials:

1,3,4,6-tetraphenyl-piperazine-2,5-dione

ethyl N-phenyl-α-phenylglycinate

N-phenyl-2-phenylglycine

2-methyl-2,3,4-triphenyl-[1,3,2]oxazasilolidin-5-one

Refernces

• 1、 Naito, Yuki,Nakamura, Yuto,Shida, Naoki,Senboku, Hisanori,Tanaka, Kenta,Atobe, Mahito. "Integrated Flow Synthesis of α-Amino Acids byIn SituGeneration of Aldimines and Subsequent Electrochemical Carboxylation". . p. 15953 - 15960. Retrieved 2021/07/20.
• 2、 Sathe, Ajay A.,Hartline, Douglas R.,Radosevich, Alexander T.. "A synthesis of α-amino acids via direct reductive carboxylation of imines with carbon dioxide". supporting information. p. 5040 - 5042. Retrieved 2013/06/05.