A-BROMO-1-[(1,1-DIMETHYLETHOXY)CARBONYL]-4-PIPERIDINEACETIC ACID

Base Information

• Chemical Name: A-BROMO-1-[(1,1-DIMETHYLETHOXY)CARBONYL]-4-PIPERIDINEACETIC ACID
• CAS No.: 881016-89-3
• Molecular Formula: C₁₂H₂₀BrNO₄
• Molecular Weight: 322.199
• Hs Code.: 2933399090
• Mol file: 881016-89-3.mol

Synonyms:4-(bromo-carboxy-methyl)-piperidine-1-carboxylic acid tert-butyl ester;A-BROMO-1-[(1,1-DIMETHYLETHOXY)CARBONYL]-4-PIPERIDINEACETIC ACID;

Chemical Property of A-BROMO-1-[(1,1-DIMETHYLETHOXY)CARBONYL]-4-PIPERIDINEACETIC ACID

Chemical Property:

• PSA: 66.84000
• LogP: 2.41950

Purity/Quality:

≥99% ^*data from raw suppliers

ALPHA-BROMO-1-[(1,1-DIMETHYLETHOXY)CARBONYL]-4-PIPERIDINEACETIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of A-BROMO-1-[(1,1-DIMETHYLETHOXY)CARBONYL]-4-PIPERIDINEACETIC ACID

There total 5 articles about A-BROMO-1-[(1,1-DIMETHYLETHOXY)CARBONYL]-4-PIPERIDINEACETIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

4-(bromo-methoxycarbonyl-methyl)-piperidine-1-carboxylic acid tert-butyl ester (881016-88-2) → 4-(bromo-carboxy-methyl)-piperidine-1-carboxylic acid tert-butyl ester (881016-89-3)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃;

DOI:10.1021/jm070902b

Reference yield:

C12H19BrNO4(1-)*Li(1+) → 4-(bromo-carboxy-methyl)-piperidine-1-carboxylic acid tert-butyl ester (881016-89-3)

Guidance literature:

With hydrogenchloride; In water;

Reference yield:

4-piperidine acetic acid methyl ester (168986-49-0) → 4-(bromo-carboxy-methyl)-piperidine-1-carboxylic acid tert-butyl ester (881016-89-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 4 h / -78 °C

2.2: 2.5 h / -78 - 0 °C

3.1: lithium hydroxide; water / methanol; tetrahydrofuran / 3 h / 20 °C

With water; triethylamine; lithium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane;

upstream raw materials:

4-(bromo-methoxycarbonyl-methyl)-piperidine-1-carboxylic acid tert-butyl ester

4-piperidine acetic acid methyl ester

1-t-Butoxycarbonyl-4-(methoxycarbonylmethyl)piperidine

di-tert-butyl dicarbonate

Refernces

• 1、 -. "SUBSTITUTED PYRIDINES AS INHIBITORS OF DNMT1". Page/Page column 728. . Retrieved 2018/01/20.