Carumonam

Base Information

• Chemical Name: Carumonam
• CAS No.: 87638-04-8
• Deprecated CAS: 93713-10-1
• Molecular Formula: C₁₂H₁₄N₆O₁₀S₂
• Molecular Weight: 466.409
• UNII: 486890PI06
• DSSTox Substance ID: DTXSID3048312
• Wikipedia: Carumonam
• Wikidata: Q76390952
• NCI Thesaurus Code: C79879
• Metabolomics Workbench ID: 58864
• ChEMBL ID: CHEMBL1614658
• Mol file: 87638-04-8.mol

Synonyms:AMA 1080;AMA-1080;carumonam;Ro 17-2301;Ro-17-2301

Chemical Property of Carumonam

Chemical Property:

• Boiling Point: °Cat760mmHg
• PKA: -0.43±0.60(Predicted)
• Flash Point: °C
• PSA: 290.52000
• Density: 2.13g/cm³
• LogP: -0.18460
• XLogP3: -1.4
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 14
• Rotatable Bond Count: 10
• Exact Mass: 466.02128301
• Heavy Atom Count: 30
• Complexity: 858

Purity/Quality:

99% ^*data from raw suppliers

CARUMONAM 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(N=C(S1)N)C(=NOCC(=O)O)C(=O)NC2C(N(C2=O)S(=O)(=O)O)COC(=O)N
• Isomeric SMILES: C1=C(N=C(S1)N)/C(=N/OCC(=O)O)/C(=O)N[C@H]2[C@H](N(C2=O)S(=O)(=O)O)COC(=O)N
• Description: Canunonam is an injectable antibiotic, the second monobactam ever developed (the first being Squibb’s aztreonam). It is highly active against Gram negative bacteria, particularly pseudomom, and is reportedly effective in the treatment of pneumonia, cystitis, peritonitis and secondary infections.

Technology Process of Carumonam

There total 1 articles about Carumonam which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3S,4S)-3-amino-4-[(carbamoyloxy)methyl]-2-oxo-azetidine-1-sulfonic acid (88852-06-6) → Carumonam (87638-04-8,97591-32-7,97591-42-9)

Guidance literature:

DOI:10.1248/cpb.33.3798

upstream raw materials:

(3S,4S)-3-amino-4-[(carbamoyloxy)methyl]-2-oxo-azetidine-1-sulfonic acid

Refernces