2-Propionylfuran

Base Information

• Chemical Name: 2-Propionylfuran
• CAS No.: 3194-15-8
• Molecular Formula: C7H8O2
• Molecular Weight: 124.139
• Hs Code.: 2932190090
• European Community (EC) Number: 221-693-8
• NSC Number: 27357
• UNII: PLX6ML3WN6
• DSSTox Substance ID: DTXSID30185778
• Nikkaji Number: J45.584I
• Wikidata: Q63408623
• Metabolomics Workbench ID: 48964
• Mol file: 3194-15-8.mol

Synonyms:2-Propionylfuran;3194-15-8;1-(furan-2-yl)propan-1-one;1-(2-Furyl)propan-1-one;1-Propanone, 1-(2-furanyl)-;Furyl ethyl ketone;2-Furyl ethyl ketone;Ethyl 2-furyl ketone;1-(2-Furyl)-1-propanone;1-(2-furanyl)-1-propanone;1-Propanone, 1-(2-furyl)-;ETHYL FURYL KETONE;2-Propanoylfuran;1-Furan-2-yl-propan-1-one;PLX6ML3WN6;EINECS 221-693-8;NSC-27357;AI3-23587;Ethylfurylketone;UNII-PLX6ML3WN6;1-(2-Furanyl)-propanone;SCHEMBL574955;1-(uran-2-yl)propan-1-one;1-(2-Furyl)-1-propanone #;1-(furan-2-yl)-propan-1-one;DTXSID30185778;CHEBI:178478;NSC27357;MFCD00020936;NSC 27357;AKOS000296108;1-(2-Furyl)-1-propanone, AldrichCPR;AS-58927;CS-0216903;FT-0634720;EN300-64635;N11989;J-018573;Q63408623;Z274774438

Chemical Property of 2-Propionylfuran

Chemical Property:

• Vapor Pressure: 0.677mmHg at 25°C
• Melting Point: 26-30℃
• Refractive Index: 1.464
• Boiling Point: 186 °C at 760 mmHg
• Flash Point: 78.3 °C
• PSA: 30.21000
• Density: 1.032 g/cm³
• LogP: 1.87230
• Storage Temp.: -20°C Freezer
• Solubility.: Acetone (Sparingly), Methanol (Slightly)
• XLogP3: 1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 124.052429494
• Heavy Atom Count: 9
• Complexity: 110

Purity/Quality:

99% ^*data from raw suppliers

1-(Furan-2-yl)propan-1-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC(=O)C1=CC=CO1

Technology Process of 2-Propionylfuran

There total 21 articles about 2-Propionylfuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

furan (110-00-9) + propionic acid (802294-64-0,79-09-4) → 2-propionylfuran (3194-15-8)

Guidance literature:

With trifluoroacetic anhydride; Duolite ES 467 H⁺ phosphonic resin; In nitromethane; at 25 ℃; for 0.5h;

Reference yield: 94.0%

ethylfurfuryl alcohol (4208-61-1,119619-55-5,127418-31-9,128948-40-3) → 2-propionylfuran (3194-15-8)

Guidance literature:

With [bis(acetoxy)iodo]benzene; BF₄^(1-)*C₁₉H₃₂N₆O₂⁽¹⁺⁾; In dichloromethane; at 20 ℃; for 0.05h;

DOI:10.1016/j.tetlet.2010.06.086

Reference yield: 91.0%

1-(furan-2-yl)-2-propen-1-ol (119619-38-4) → 2-propionylfuran (3194-15-8)

Guidance literature:

With C₃₀H₂₉BrMnNO₂P₂; potassium tert-butylate; In toluene; at 120 ℃; for 1h;

DOI:10.1039/c9cy01502g

upstream raw materials:

Diazoethan

furfural

furan

propionyl chloride

Downstream raw materials:

2-(2-furyl)-2-butanol

2-propylfuran

2-propionylpyrrole

2-ethylpyridin-3-ol

Refernces

• 1、 Zhan, Huan,Cui, Heping,Yu, Junhe,Hayat, Khizar,Wu, Xian,Zhang, Xiaoming,Ho, Chi-Tang. "Characteristic flavor formation of thermally processed N-(1-deoxy-α-D-ribulos-1-yl)-glycine: Decisive role of additional amino acids and promotional effect of glyoxal". . . Retrieved 2021/09/28.
• 2、 Spiegelberg, Brian,Dell'Acqua, Andrea,Xia, Tian,Spannenberg, Anke,Tin, Sergey,Hinze, Sandra,de Vries, Johannes G.. "Additive-Free Isomerization of Allylic Alcohols to Ketones with a Cobalt PNP Pincer Catalyst". supporting information. p. 7820 - 7825. Retrieved 2019/05/22.