4-Acetamidobenzenesulfonamide

Base Information

• Chemical Name: 4-Acetamidobenzenesulfonamide
• CAS No.: 121-61-9
• Molecular Formula: C8H10N2O3S
• Molecular Weight: 214.245
• Hs Code.: 2935009090
• European Community (EC) Number: 204-486-7
• NSC Number: 406839,217
• UNII: 340484WZ3L
• DSSTox Substance ID: DTXSID4041529
• Nikkaji Number: J5.342B
• Wikidata: Q27256303
• Pharos Ligand ID: NUNQN2WLNPK8
• ChEMBL ID: CHEMBL687
• Mol file: 121-61-9.mol

Synonyms:Acetopt;Acetylsulfanilamide;AK Sulf;AK-Sulf;Albucid;Antébor;Belph 10;Belph-10;Bleph;Ceta Sulfa;Cetamide;Colircusi Sulfacetamida;Coliriocilina Sulfacetam;Isopto Cetamide;Sodium Sulamyd;Sulamyd, Sodium;Sulf 10;Sulf-10;Sulfacetam, Coliriocilina;Sulfacetamida, Colircusi;Sulfacetamide;Sulfacetamide Monosodium Salt;Sulfacetamide Sodium;Sulfacetamide, Monosodium Salt, Anhydrous;Sulfacil;Sulfacyl;Sulfair;Sulphacetamide

Chemical Property of 4-Acetamidobenzenesulfonamide

Chemical Property:

• Appearance/Colour: White to light beige crystalline powder
• Vapor Pressure: 0Pa at 25℃
• Melting Point: 214-217 °C
• Refractive Index: 1.605
• Boiling Point: 418.91℃[at 101 325 Pa]
• PKA: 9.88±0.12(Predicted)
• PSA: 97.64000
• Density: 1.414 g/cm³
• LogP: 2.14650
• Storage Temp.: Room Temperature
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• Water Solubility.: slightly soluble
• XLogP3: 0
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 214.04121336
• Heavy Atom Count: 14
• Complexity: 299

Purity/Quality:

99.9% ^*data from raw suppliers

p-Sulfamylacetanilide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NC1=CC=C(C=C1)S(=O)(=O)N
• Uses: 4-Acetamidobenzenesulfonamide has been used as an inhibitor of mitochondrial isoenzyme carbonic anhydrase V inhibitiors. Vullo, Daniela p-Sulfamylacetanilide has been used as an inhibitor of mitochondrial isoenzyme carbonic anhydrase V inhibitiors. Vullo, Daniela

Technology Process of 4-Acetamidobenzenesulfonamide

There total 43 articles about 4-Acetamidobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.8%

ethyl o-vinylbenzoyl acetate (579479-65-5) → ethyl (o-vinylbenzoyl)diazoacetate (579479-51-9) + p-acetylaminobenzenesulfonamide (121-61-9)

Guidance literature:

With 4-acetamidobenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 0 - 20 ℃; for 16h;

Reference yield: 90.0%

N-Isopropyl-p-acetamido-benzol-sulfonamid (91430-85-2) → p-acetylaminobenzenesulfonamide (121-61-9)

Guidance literature:

With chromium(III) acetate hydroxide; periodic acid; In acetonitrile; at 20 ℃; for 14h;

DOI:10.1055/s-2004-830851

Reference yield: 87.0%

N-[4-({(E)-[methyl(phenyl)amino]methylidene}sulfamoyl)phenyl]acetamide → p-acetylaminobenzenesulfonamide (121-61-9)

Guidance literature:

With hydrazine hydrate; In ethanol; at 20 ℃; for 1.5h;

DOI:10.1002/ejoc.201300402

upstream raw materials:

acetic anhydride

acetic acid

sulfanilamide

p-acetylaminobenzenesulfonyl chloride

Downstream raw materials:

4'-(thiazol-2-ylsulfamoyl)acetanilide

4'-(pyrimidin-2-ylsulfamoyl)acetanilide

N-(4-{[(4-methyl-2-thiazolyl)amino]sulfonyl}phenyl)-acetamide

(N-acetyl-sulfanilyl)-nicotinoyl-amine

Refernces

• 1、 Mei, Hua,Ibrahim, Faisal. "Two New Diazonium Bis(perfluoroalkyl)arylsulfonyl Imide Zwitterionic Monomers from Perfluoro(3-oxa-4-pentene)sulfonyl Fluoride for Proton Exchange Membrane Fuel Cells". . p. 46 - 51. Retrieved 2017.
• 2、 Patel, Tarosh S.,Vanparia, Satish F.,Gandhi, Sahaj A.,Patel, Urmila H.,Dixit, Ritu B.,Chudasama, Chaitanya J.,Dixit, Bharat C.. "Novel stereoselective 2,3-disubstituted quinazoline-4(3H)-one derivatives derived from glycine as a potent antimalarial lead". . p. 8638 - 8649. Retrieved 2015.
• 3、 Geng, Jin,Zhang, Yichuan,Gao, Quan,Neumann, Kevin,Dong, Hua,Porter, Hamish,Potter, Mark,Ren, Hua,Argyle, David,Bradley, Mark. "Switching on prodrugs using radiotherapy". . p. 805 - 810. Retrieved 2021.
• 4、 Imamura,Sonoda,Arimori,Ichibagase. "Effect of simultaneous administration of drugs on absorption and excretion. X. Plasma protein binding of carbutamide in rabbits". . p. 463 - 467. Retrieved 1979.
• 5、 Xuan,Zhan,Zhang,Li,Zheng. "Inhibition of carbonic anhydrase II by sulfonamide derivatives". . p. 412 - 415. Retrieved 2021/11/22.