5-METHYLPYRIMIDIN-4-OL

Base Information

• Chemical Name: 5-METHYLPYRIMIDIN-4-OL
• CAS No.: 17758-52-0
• Molecular Formula: C5H6N2O
• Molecular Weight: 110.115
• Mol file: 17758-52-0.mol

Synonyms:4(1H)-Pyrimidinone,5-methyl- (9CI);4(3H)-Pyrimidinone, 5-methyl- (6CI);4-Pyrimidinol, 5-methyl-(8CI);4-Hydroxy-5-methylpyrimidine;5-Methyl-4-hydroxypyrimidine;NSC 618281;

Chemical Property of 5-METHYLPYRIMIDIN-4-OL

Chemical Property:

• Vapor Pressure: 0.045mmHg at 25°C
• Melting Point: 153-154 °C
• Refractive Index: 1.557
• Boiling Point: 192.1°Cat760mmHg
• PKA: 9.18±0.40(Predicted)
• Flash Point: 70°C
• PSA: 46.01000
• Density: 1.22g/cm³
• LogP: 0.49060
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Hydroxy-5-methylpyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-METHYLPYRIMIDIN-4-OL

There total 5 articles about 5-METHYLPYRIMIDIN-4-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-thiothymine (636-26-0) → 5-methyl-4(3H)-pyrimidinone (17758-52-0)

Guidance literature:

With ammonia; Raney-Nickel; In water; for 16h; Reflux;

Reference yield: 7.0%

5-methyl-2-thiouracil (636-26-0) → 5-methyl-4(3H)-pyrimidinone (17758-52-0) + thymin (65-71-4,28806-14-6,691841-57-3)

Guidance literature:

With oxygen; ozone; In acetic acid; for 0.166667h; Ambient temperature;

DOI:10.1246/bcsj.62.2939

Reference yield:

5-methyl-2-thiouracil (636-26-0) → 5-methyl-4(3H)-pyrimidinone (17758-52-0)

Guidance literature:

With dihydrogen peroxide;

DOI:10.1021/ja01282a028

upstream raw materials:

5-methyl-2-thiouracil

dihydrogen peroxide

2-thiothymine

Downstream raw materials:

4-Amino-5-methylpyrimidin

4-chloro-5-methyl-pyrimidine

5-methylpyrimidine

pyrimidine-5-carboxylic acid

Refernces

• 1、 Matsui,Kamiya,Kawamura,Shibata,Muramatsu. "Ozonization of thio- and azauracils". . p. 2939 - 2941. Retrieved 2007/10/02.