Technology Process of 1-Benzyl-1,2,3,6-tetrahydropyridine-2-carbonitrile
There total 7 articles about 1-Benzyl-1,2,3,6-tetrahydropyridine-2-carbonitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
N-benzylpyridinium hexafluorophosphate;
With
lithium triethylborohydride;
In
tetrahydrofuran;
at -70 - 0 ℃;
for 1h;
Schlenk technique;
Inert atmosphere;
sodium cyanide;
With
hydrogenchloride;
In
tetrahydrofuran; water;
at 0 ℃;
pH=9.5;
Schlenk technique;
Inert atmosphere;
DOI:10.1002/ejoc.201300595
- Guidance literature:
-
With
aluminum oxide;
In
dichloromethane;
for 12h;
Ambient temperature;
DOI:10.1021/jo00187a018
- Guidance literature:
-
Multi-step reaction with 4 steps
1: NaBH4 / ethanol / Ambient temperature
2: m-chloroperbenzoic acid / CH2Cl2 / 40 °C
3: 1) (CF3CO)2O / 1) CH2Cl2, 1 h, r.t. 2) 30 min, r.t., pH 4.0 (NaOAc or AcOH)
4: 50 percent / alumina / CH2Cl2 / 12 h / Ambient temperature
With
aluminum oxide; sodium tetrahydroborate; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride;
In
ethanol; dichloromethane;
DOI:10.1021/jo00187a018
