Enzastaurin

Base Information Edit

Chemical Name:Enzastaurin
CAS No.:170364-57-5
Molecular Formula:C₃₂H₂₉N₅O₂
Molecular Weight:515.615
Hs Code.:29339900
European Community (EC) Number:806-090-5
UNII:UC96G28EQF
DSSTox Substance ID:DTXSID5044029
Nikkaji Number:J1.692.444J
Wikipedia:Enzastaurin
Wikidata:Q5381479
NCI Thesaurus Code:C77392
Pharos Ligand ID:LSYLPJPK7GJ2
Metabolomics Workbench ID:149805
ChEMBL ID:CHEMBL300138
Mol file:170364-57-5.mol

Synonyms:enzastaurin;LY317615.HCl

Suppliers and Price of Enzastaurin

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Enzastaurin
50mg
$ 825.00

Tocris
Enzastaurin ≥98%(HPLC)
50
$ 609.00

Tocris
Enzastaurin ≥98%(HPLC)
10
$ 145.00

Sigma-Aldrich
Enzastaurin ≥98% (HPLC)
25mg
$ 404.00

Sigma-Aldrich
Enzastaurin ≥98% (HPLC)
5mg
$ 106.00

Matrix Scientific
3-(1-Methyl-1H-indol-3-yl)-4-(1-(1-(pyridin-2-ylmethyl)-piperidin-4-yl)-1H-indol-3-yl)-1H-pyrrole-2,5-dione 95+%
1g
$ 2268.00

Matrix Scientific
3-(1-Methyl-1H-indol-3-yl)-4-(1-(1-(pyridin-2-ylmethyl)-piperidin-4-yl)-1H-indol-3-yl)-1H-pyrrole-2,5-dione 95+%
250mg
$ 1021.00

DC Chemicals
Enzastaurin(LY317615) >98%
250 mg
$ 600.00

CSNpharm
Enzastaurin
5mg
$ 43.00

CSNpharm
Enzastaurin
10mg
$ 60.00

Total 61 raw suppliers

Chemical Property of Enzastaurin Edit

Chemical Property:

Vapor Pressure:1.87E-23mmHg at 25°C
Melting Point:249-261℃
Refractive Index:1.722
Boiling Point:767.2 °C at 760 mmHg
PKA:7.88±0.60(Predicted)
Flash Point:417.8 °C
PSA：72.16000
Density:1.34 g/cm³
LogP:5.19900
Storage Temp.:?20°C
Solubility.:DMSO: soluble10mg/mL, clear (warmed)
XLogP3:3.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:515.23212518
Heavy Atom Count:39
Complexity:974

Purity/Quality:

98% ^*data from raw suppliers

Enzastaurin ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 22

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CN(C5=CC=CC=C54)C6CCN(CC6)CC7=CC=CC=N7
Recent ClinicalTrials:Investigate Efficacy, Safety, and Pharmacokinetics of Enzastaurin for the Prevention of Arterial Events in Patients With Vascular Ehlers-Danlos Syndrome.
Recent EU Clinical Trials:A multicenter, randomized, double-blind, placebo-controlled study of enzastaurin for the prevention of arterial events in patients with vascular Ehlers-Danlos Syndrome (vEDS) confirmed with COL3A1 mutations, followed by an open label extension (OLE)
Description Enzastaurin (170364-57-5) is a potent and selective PKCβ inhibitor.? IC50 = 6, 39, 83 and 110 nM, for PKCβ, PKCα, PKCγ and PKCε respectively.1 Induces apoptosis in multiple myeloma cell lines via inhibition of the AKT signaling pathway.2 Induces mitotic missegregation and preferential cytotoxicity in colorectal cancer cells with chromosomal instability.3 Attenuates amphetamine-stimulated dopamine efflux.4 Inhibits blood-brain barrier leakiness in a mouse model.5
Uses PKCβ-selective inhibitor, suppresses angiogenesis. Enzastaurin has been used in splicing analysis to study its effects on splicing of a mutated exon.

Technology Process of Enzastaurin

There total 27 articles about Enzastaurin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%