pyridin-2-yl(thiazol-2-yl)Methanone

Base Information

• Chemical Name: pyridin-2-yl(thiazol-2-yl)Methanone
• CAS No.: 90418-58-9
• Molecular Formula: C₉H₆N₂OS
• Molecular Weight: 190.225
• Hs Code.: 2934100090
• Mol file: 90418-58-9.mol

Synonyms:[Pyridyl-(2)]-[thiazolyl-(2)]-keton;Pyridin-2-yl(thiazol-2-yl)methanone;

Chemical Property of pyridin-2-yl(thiazol-2-yl)Methanone

Chemical Property:

• PSA: 71.09000
• LogP: 1.76910

Purity/Quality:

98%,99%, ^*data from raw suppliers

pyridin-2-yl(thiazol-2-yl)methanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of pyridin-2-yl(thiazol-2-yl)Methanone

There total 2 articles about pyridin-2-yl(thiazol-2-yl)Methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

pyridine-2-carbaldehyde (1121-60-4) + 2-(trimethylsilyl)thiazole (79265-30-8) → --keton (90418-58-9)

Guidance literature:

In dichloromethane; for 18h; Ambient temperature;

DOI:10.1021/jo00243a029

Reference yield:

2-bromo-1,3-thiazole (3034-53-5,215777-74-5) + ethyl-2-picolinate (2524-52-9,1228273-66-2) → --keton (90418-58-9)

Guidance literature:

Multistep reaction; (i) nBuLi, Et₂O, (ii)/BRN= 122485/;

Reference yield:

--keton (90418-58-9) → cyclohexyl-pyridin-2-yl-thiazol-2-yl-methanol

Guidance literature:

In diethyl ether; Heating;

upstream raw materials:

2-bromo-1,3-thiazole

ethyl-2-picolinate

pyridine-2-carbaldehyde

2-(trimethylsilyl)thiazole

Downstream raw materials:

phenyl-pyridin-2-yl-thiazol-2-yl-methanol

Refernces