1,2-Didecanoyl-sn-glycero-3-phosphocholine

Base Information

• Chemical Name: 1,2-Didecanoyl-sn-glycero-3-phosphocholine
• CAS No.: 3436-44-0
• Molecular Formula: C₂₈H₅₆NO₈P
• Molecular Weight: 565.728
• Hs Code.: 2923900090
• UNII: 66BXC7TK3J
• Metabolomics Workbench ID: 13302
• Wikidata: Q27147690
• Mol file: 3436-44-0.mol

Synonyms:1,2-dicapryl-sn-3-glycerophosphocholine;1,2-dicapryl-sn-glycero-3-phosphocholine;1,2-didecanoylphosphatidylcholine;1,2-didecanoylphosphatidylcholine, (L)-isomer;dicaprylphosphatidylcholine;didecanoyl-L-alpha-phosphatidylcholine

Chemical Property of 1,2-Didecanoyl-sn-glycero-3-phosphocholine

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 121.00000
• Density: g/cm³
• LogP: 7.00080
• Storage Temp.: −20°C
• XLogP3: 7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 28
• Exact Mass: 565.37435474
• Heavy Atom Count: 38
• Complexity: 645

Purity/Quality:

99% ^*data from raw suppliers

1,2-DidecanoylPC ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCCCCCCCCC(=O)OCC(COP(=O)([O-])OCC[N+](C)(C)C)OC(=O)CCCCCCCCC
• Isomeric SMILES: CCCCCCCCCC(=O)OC[C@H](COP(=O)([O-])OCC[N+](C)(C)C)OC(=O)CCCCCCCCC
• Description: Phosphatidylcholine species are a common class of phospholipids that comprise the mammalian cell membrane. 1,2-Didecanoyl PC (DPC) is a synthetic, less hydrophobic phospholipid that has been found to be useful for enhancing the absorption of peptide drugs and hormones such as insulin. Thus, the bioavailability of intranasally applied human growth hormone is enhanced when coadministered with the absorption enhancer DPC.
• Uses: 1,2-Didecanoyl PC is a synthetic phospholipid.

Technology Process of 1,2-Didecanoyl-sn-glycero-3-phosphocholine

There total 2 articles about 1,2-Didecanoyl-sn-glycero-3-phosphocholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 1,2-didecanoyl-sn-glycero-3-phosphocholine (3436-44-0)

Guidance literature:

With ethanol; platinum; Hydrogenation;

DOI:10.1021/ja01519a051

Reference yield:

L-glycero-3-phosphorylcholine (28319-77-9,563-24-6) + n-decanoyl chloride (112-13-0) → 1,2-didecanoyl-sn-glycero-3-phosphocholine (3436-44-0)

Guidance literature:

In chloroform;

Reference yield:

1,2-didecanoyl-sn-glycero-3-phosphocholine (3436-44-0) → (S)-1,2-O-didecanoyl-sn-glycerol (60514-49-0,82950-64-9) + choline phosphate (645-84-1)

Guidance literature:

With Tris-HCl buffer; at 37 ℃; pH=7.4; Enzyme kinetics;

DOI:10.1021/ac701672g

upstream raw materials:

L-glycero-3-phosphorylcholine

n-decanoyl chloride

Downstream raw materials:

(S)-1,2-O-didecanoyl-sn-glycerol

choline phosphate