Erythromycin propionate

Base Information

• Chemical Name: Erythromycin propionate
• CAS No.: 134-36-1
• Molecular Formula: C40H71 N O14
• Molecular Weight: 790.002
• European Community (EC) Number: 205-140-8
• UNII: HB75CIT999
• DSSTox Substance ID: DTXSID9022994
• Nikkaji Number: J5.592A
• Wikidata: Q27121386
• NCI Thesaurus Code: C169960
• Metabolomics Workbench ID: 57124
• ChEMBL ID: CHEMBL2220427
• Mol file: 134-36-1.mol

Synonyms:erythromycin propionate;propionyl eryhthromycin

Chemical Property of Erythromycin propionate

Chemical Property:

• Vapor Pressure: 8.87E-32mmHg at 25°C
• Melting Point: 122-126 C
• Boiling Point: 827.7°Cat760mmHg
• Flash Point: 454.4°C
• PSA: 199.98000
• Density: 1.19g/cm³
• LogP: 2.74650
• XLogP3: 3.7
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 15
• Rotatable Bond Count: 10
• Exact Mass: 789.48745594
• Heavy Atom Count: 55
• Complexity: 1300

Purity/Quality:

99%, ^*data from raw suppliers

ERYTHROMYCIN PROPIONATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC1C(C(C(C(=O)C(CC(C(C(C(C(C(=O)O1)C)OC2CC(C(C(O2)C)O)(C)OC)C)OC3C(C(CC(O3)C)N(C)C)OC(=O)CC)(C)O)C)C)O)(C)O
• Isomeric SMILES: CC[C@@H]1[C@@]([C@@H]([C@H](C(=O)[C@@H](C[C@@]([C@@H]([C@H]([C@@H]([C@H](C(=O)O1)C)O[C@H]2C[C@@]([C@H]([C@@H](O2)C)O)(C)OC)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)OC(=O)CC)(C)O)C)C)O)(C)O
• Uses: Antibacterial.

Technology Process of Erythromycin propionate

There total 3 articles about Erythromycin propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

propionic acid anhydride (123-62-6) + erythromycin (114-07-8) → C46H79NO16 + C43H75NO15 + 2',4-dipropionylerythromycin + erythromycin propionate (134-36-1)

Guidance literature:

With C₄₇H₆₂N₈O₁₀; triethylamine; In chloroform; at 20 ℃; for 22h; Inert atmosphere;

DOI:10.1016/j.bmcl.2008.09.019

Reference yield:

propionyl chloride (79-03-8) + erythromycin (114-07-8) → erythromycin propionate (134-36-1)

Guidance literature:

With magnesium oxide; benzene;

Reference yield:

propionic acid anhydride (123-62-6) + erythromycin (114-07-8) → erythromycin propionate (134-36-1)

Guidance literature:

With acetone;

upstream raw materials:

propionyl chloride

erythromycin

propionic acid anhydride

Refernces

• 1、 Lewis, Chad A.,Miller, Scott J.. "Site-selective derivatization and remodeling of erythromycin A by using simple peptide-based chiral catalysts". . p. 5616 - 5619. Retrieved 2008/02/04.