Rifalazil

Base Information

• Chemical Name: Rifalazil
• CAS No.: 129791-92-0
• Molecular Formula: C₅₁H₆₄N₄O₁₃
• Molecular Weight: 941.088
• Mol file: 129791-92-0.mol

Synonyms:KRM 1648;Rifalazil;

Chemical Property of Rifalazil

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 195-200° (dec)
• Refractive Index: 1.634
• Boiling Point: 1048.6°Cat760mmHg
• Flash Point: 588°C
• PSA: 230.66000
• Density: 1.36g/cm³
• LogP: 6.57360

Purity/Quality:

98%Min ^*data from raw suppliers

Rifalazil ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Antibacterial (antimycobacterial). Rifalazil has been used as a part of multi drug regimen in the treatment of tuberculosis.

Technology Process of Rifalazil

There total 4 articles about Rifalazil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

1-isobutylpiperazine (5308-28-1) + 3'-tert-butyldimethylsilyloxybenzoxazinorifamycin (143526-61-8) → rifalazil (129791-92-0)

Guidance literature:

With manganese(IV) oxide; In dimethyl sulfoxide; for 24h; Ambient temperature;

DOI:10.1248/cpb.41.148

Reference yield:

1-isobutylpiperazine (5308-28-1) + 3'-hydroxy-benzoxazinorifamycin (105396-63-2) → rifalazil (129791-92-0)

Guidance literature:

With manganese(IV) oxide; In dimethyl sulfoxide; at 20 ℃;

DOI:10.1016/j.bmcl.2007.08.048

Reference yield:

2-aminoresorcinol hydrochloride (634-60-6) → rifalazil (129791-92-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 79 percent / triethylamine / dimethylformamide / 15 h / Ambient temperature

2: 2.) manganese dioxide / 1.) toluene, RT, 17 h, 2.) ethanol, RT, 30 min

3: 53 percent / manganese dioxide / dimethylsulfoxide / 24 h / Ambient temperature

With manganese(IV) oxide; triethylamine; In dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1248/cpb.41.148

upstream raw materials:

1-isobutylpiperazine

3'-tert-butyldimethylsilyloxybenzoxazinorifamycin

3'-hydroxy-benzoxazinorifamycin

2-aminoresorcinol hydrochloride

Refernces

• 1、 Yamane,Hashizume,Yamashita,Konishi,Hosoe,Hidaka,Watanabe,Kawaharada,Yamamoto,Kuze. "Synthesis and biological activity of 3'-hydroxy-5'-aminobenzoxazinorifamycin derivatives". . p. 148 - 155. Retrieved 2007/10/02.