5-(1,3-BENZOTHIAZOL-2-YL)-2-FURALDEHYDE

Base Information

• Chemical Name: 5-(1,3-BENZOTHIAZOL-2-YL)-2-FURALDEHYDE
• CAS No.: 34653-56-0
• Molecular Formula: C12H7NO2S
• Molecular Weight: 229.259
• Hs Code.: 2934200090
• Mol file: 34653-56-0.mol

Synonyms:5-(2-Benzothiazolyl)furfural;5-(1,3-Benzothiazol-2-yl)-2-furaldehyde;5-(1,3-Benzothiazol-2-yl)furan-2-carbaldehyde;5-Benzothiazol-2-ylfuran-2-carbaldehyde;5-Benzothiazol-2-yl-furan-2-carbaldehyde;

Chemical Property of 5-(1,3-BENZOTHIAZOL-2-YL)-2-FURALDEHYDE

Chemical Property:

• Vapor Pressure: 1.19E-07mmHg at 25°C
• Melting Point: 176 °C
• Refractive Index: 1.7
• Boiling Point: 431.5 °C at 760 mmHg
• PKA: 1.08±0.10(Predicted)
• Flash Point: 214.8 °C
• PSA: 67.59000
• Density: 1.381 g/cm³
• LogP: 1.90380

Purity/Quality:

98%min ^*data from raw suppliers

5-(1,3-Benzothiazol-2-yl)-2-furaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-(1,3-BENZOTHIAZOL-2-YL)-2-FURALDEHYDE

There total 8 articles about 5-(1,3-BENZOTHIAZOL-2-YL)-2-FURALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-(furan-2-yl)-1,3-benzothiazole (1569-98-8) + hexamethylenetetramine (100-97-0) → 5-(1,3-benzothiazol-2-yl)furan-2-carbaldehyde (34653-56-0)

Guidance literature:

With PPA; at 80 - 90 ℃; for 3h;

DOI:10.1007/s10593-008-0156-8

Reference yield: 88.0%

furfural (98-01-1) + 1,3-Benzothiazole (95-16-9) → 5-(1,3-benzothiazol-2-yl)furan-2-carbaldehyde (34653-56-0)

Guidance literature:

With C₇₈H₈₆Cl₂N₄Pd₂; silver(I) acetate; In dimethyl sulfoxide; at 110 ℃; for 24h; Sealed tube;

DOI:10.1021/acs.joc.8b01053

Reference yield: 74.0%

2-(furan-2-yl)-1,3-benzothiazole (1569-98-8) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 5-(1,3-benzothiazol-2-yl)furan-2-carbaldehyde (34653-56-0)

Guidance literature:

With trichlorophosphate; at 100 ℃; for 2h;

DOI:10.1016/S0957-4166(03)00025-9

upstream raw materials:

2-(furan-2-yl)-1,3-benzothiazole

N,N-dimethyl-formamide

2-furancarbonyl chloride

2-amino-benzenethiol

Downstream raw materials:

(E)-2-{5-[2-(4-dimethylaminophenyl)-vinyl]-furan-2-yl}-benzothiazole

Refernces

• 1、 Chen, Xuxing,Huang, Xiaojing,He, Qian,Xie, Yuyuan,Yang, Chunhao. "Palladium-catalyzed oxidative C-H/C-H cross-coupling of benzothiazoles with thiophenes and thiazoles". supporting information. p. 3996 - 3999. Retrieved 2014/04/03.
• 2、 Melnikova,Elchaninov,Milov,Lukyanov. "Synthesis and properties of 2-(2-furyl)benzothiazole". experimental part. p. 1070 - 1076. Retrieved 2009/05/26.