Benzamide,N-[3-(2-pyridinyl)-1-isoquinolinyl]-

Base Information

• Chemical Name: Benzamide,N-[3-(2-pyridinyl)-1-isoquinolinyl]-
• CAS No.: 112575-48-1
• Molecular Formula: C21H15 N3 O
• Molecular Weight: 325.36
• Mol file: 112575-48-1.mol

Synonyms:VUF 8507

Chemical Property of Benzamide,N-[3-(2-pyridinyl)-1-isoquinolinyl]-

Chemical Property:

• PSA: 54.88000
• LogP: 4.62210

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzamide,N-[3-(2-pyridinyl)-1-isoquinolinyl]-

There total 3 articles about Benzamide,N-[3-(2-pyridinyl)-1-isoquinolinyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

benzoyl chloride (98-88-4) + 1-amino-3-(2-pyridinyl)isoquinoline (37989-04-1) → VUF 8507 (112575-48-1)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; at -10 ℃; for 1h;

DOI:10.1021/jm00399a005

Reference yield:

2-Methylbenzonitrile (529-19-1) → VUF 8507 (112575-48-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 58 percent / KNH₂, NH₃(liq.), ferric nitrate / tetrahydrofuran / Ambient temperature

2: 1.) n-BuLi / 1.) THF, hexane, -10 deg C, 10 min, 2.) THF, -10 deg C, 1 h

With n-butyllithium; ammonia; potassium amide; ferric nitrate; In tetrahydrofuran;

DOI:10.1021/jm980037i

Reference yield:

2-Cyanopyridine (100-70-9,1232006-36-8) → VUF 8507 (112575-48-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 58 percent / KNH₂, NH₃(liq.), ferric nitrate / tetrahydrofuran / Ambient temperature

2: 1.) n-BuLi / 1.) THF, hexane, -10 deg C, 10 min, 2.) THF, -10 deg C, 1 h

With n-butyllithium; ammonia; potassium amide; ferric nitrate; In tetrahydrofuran;

DOI:10.1021/jm980037i

upstream raw materials:

benzoyl chloride

1-amino-3-(2-pyridinyl)isoquinoline

2-Cyanopyridine

2-Methylbenzonitrile

Refernces

• 1、 Zwart, Marcel A. H. de,Goot, Henk van der,Timmerman, Henk. "Synthesis and Copper-Dependent Antimycoplasmal Activity of 1-Amino-3-(2-pyridyl)isoquinoline Derivatives. 1. Amides". . p. 716 - 722. Retrieved 2007/10/02.