Oxiconazole nitrate

Base Information

• Chemical Name: Oxiconazole nitrate
• CAS No.: 64211-46-7
• Deprecated CAS: 104360-36-3
• Molecular Formula: C18H13Cl4N3O^.HNO3
• Molecular Weight: 492.146
• Hs Code.: 2933290000
• European Community (EC) Number: 264-730-3
• NSC Number: 758958
• UNII: RQ8UL4C17S
• DSSTox Substance ID: DTXSID2045943
• NCI Thesaurus Code: C47644
• RXCUI: 56226
• Metabolomics Workbench ID: 70766
• ChEMBL ID: CHEMBL1200836
• Mol file: 64211-46-7.mol

Synonyms:(Z)-1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)-O-(2,4-dichlorobenzyl) ethanone oxime nitrate;2',4'-dichloro-2-imidazol-1-ylacetophenone (Z)-(O-(2,4-dichlorobenzyl)oxime), mononitrate;Fonx;Gyno-Myfungar;Myfungar;Oceral;oxiconazole;oxiconazole mononitrate, (Z)-isomer;oxiconazole nitrate;Oxistat;Oxizole;oxyconazole;RO-13-8996;Salongo;Sgd 301-76

Chemical Property of Oxiconazole nitrate

Chemical Property:

• Appearance/Colour: Crystalline solid
• Vapor Pressure: 5.96E-17mmHg at 25°C
• Melting Point: 137-138 °C
• Boiling Point: 576.8 °C at 760 mmHg
• Flash Point: 302.6 °C
• PSA: 105.46000
• LogP: 6.15550
• Storage Temp.: Refrigerator
• Solubility.: Chloroform, Methanol (Sparingly)
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 6
• Exact Mass: 491.973966
• Heavy Atom Count: 30
• Complexity: 506

Purity/Quality:

99% ^*data from raw suppliers

Oxiconazole nitrate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1Cl)Cl)CON=C(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl.[N+](=O)(O)[O-]
• Isomeric SMILES: C1=CC(=C(C=C1Cl)Cl)CO/N=C(\CN2C=CN=C2)/C3=C(C=C(C=C3)Cl)Cl.[N+](=O)(O)[O-]
• Recent ClinicalTrials: A Therapeutic Equivalence Study of Two Oxiconazole Nitrate Topical Cream Treatments for Patients With Tinea Pedis
• Description: Oxiconazole nitrate is a broad-spectrum antifungal agent indicated for the treatment of skin infections due to yeasts, dermatophytes, yeast-like fungi and molds, and gram positive organisms. Oxiconazole is an antifungal imidazole that inhibits a broad spectrum of pathogenic yeasts and molds, including A. fumigatus, C. neoformans, C. albicans, and T. mentagrophytes. Its inhibitory action results from its ability to inhibit the synthesis of ergosterol, the major sterol of the fungal cell membrane.
• Uses: Topical antimycotic agent Topical aTopical antimycotic agent. agent.
• Therapeutic Function: Antifungal
• Clinical Use: (Z)-1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethanone-O-[2,4-dichlorophenyl)methyl]oxime mononitrate (Oxistat)is a white crystalline nitric acid salt. It is used in cream andlotion dosage forms in 1% concentration for the treatment oftinea pedis, tinea corporis, and tinea capitis.