ETHYL 2-ACETYL-3-OXO-HEXANOATE

Base Information

• Chemical Name: ETHYL 2-ACETYL-3-OXO-HEXANOATE
• CAS No.: 63765-76-4
• Molecular Formula: C10H16 O4
• Molecular Weight: 200.235
• Hs Code.: 2918990090
• Mol file: 63765-76-4.mol

Synonyms:ETHYL 2-ACETYL-3-OXO-HEXANOATE;2-acetyl-3-oxohexanoic acid ethyl ester;2-acetyl-3-oxo-hexanoic acid ethyl ester;Ethyl -butyryl-acetylacetate

Chemical Property of ETHYL 2-ACETYL-3-OXO-HEXANOATE

Chemical Property:

• Vapor Pressure: 0.00904mmHg at 25°C
• Boiling Point: 265.7°C at 760 mmHg
• Flash Point: 110.7°C
• PSA: 60.44000
• Density: 1.044g/cm³
• LogP: 1.12390

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 2-ACETYL-3-OXO-HEXANOATE

There total 4 articles about ETHYL 2-ACETYL-3-OXO-HEXANOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

ethyl acetoacetate (141-97-9) + butyryl chloride (141-75-3) → ethyl 3-oxo-2-acetylhexanoate (63765-76-4)

Guidance literature:

ethyl acetoacetate; With pyridine; magnesium chloride; In dichloromethane; at 0 ℃; for 0.25h; Inert atmosphere;

butyryl chloride; In dichloromethane; at 0 - 20 ℃; for 1.25h; Inert atmosphere;

DOI:10.1039/c2cc34608g DOI:10.1039/c2cc34608g

Reference yield:

ethyl acetoacetate (141-97-9) → ethyl 3-oxo-2-acetylhexanoate (63765-76-4)

Guidance literature:

With magnesium ethylate; benzene; Anschliessend Erwaermen mit Butyrylchlorid_.;

Reference yield:

butyryl chloride (141-75-3) + C6H9O3(1-)*C2H5O(1-)*Mg(2+) → ethyl 3-oxo-2-acetylhexanoate (63765-76-4)

Guidance literature:

In diethyl ether;

upstream raw materials:

ethyl acetoacetate

butyryl chloride

sodium ethyl acetylacetate enolate

Downstream raw materials:

ethyl butyroyl acetate

ethyl 3-oxooctanoate

acetamide

methyl 3-oxohexanoate

Refernces

• 1、 Betard, Angelique,Wannapaiboon, Suttipong,Fischer, Roland A.. "Assessing the adsorption selectivity of linker functionalized, moisture-stable metal-organic framework thin films by means of an environment-controlled quartz crystal microbalance". supporting information. p. 10493 - 10495. Retrieved 2013/01/15.