Dexoxadrol

Base Information

• Chemical Name: Dexoxadrol
• CAS No.: 631-06-1
• Molecular Formula: C20H23NO2•ClH
• Molecular Weight: 345.90
• Mol file: 631-06-1.mol

Synonyms:D-DIOXADROL HYDROCHLORIDE;

Chemical Property of Dexoxadrol

Chemical Property:

• Vapor Pressure: 5.26E-08mmHg at 25°C
• Melting Point: 248-254 °C
• Boiling Point: 441.9°C at 760 mmHg
• Flash Point: 187.1°C
• PSA: 30.49000
• LogP: 4.57600

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Dexoxadrol

There total 4 articles about Dexoxadrol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

dexoxadrol (4741-41-7) → (+)-dexoxadrol hydrochloride (631-06-1)

Guidance literature:

With hydrogenchloride; In ethyl acetate;

DOI:10.1016/j.tet.2013.10.082

Reference yield:

(S)-benzyl-2-vinylpiperidine-1-carboxylate (1514644-66-6) → (+)-dexoxadrol hydrochloride (631-06-1)

Guidance literature:

Multi-step reaction with 4 steps

1: AD-mix α; AD-mix β / tert-butyl alcohol; water / 0 - 20 °C

2: palladium 10% on activated carbon; hydrogen / ethanol / 6 h / 20 °C / 1900.13 Torr

3: toluene-4-sulfonic acid / isopropyl alcohol / 1 h / Reflux

4: hydrogenchloride / ethyl acetate

With hydrogenchloride; palladium 10% on activated carbon; AD-mix α; AD-mix β; hydrogen; toluene-4-sulfonic acid; In ethanol; water; ethyl acetate; isopropyl alcohol; tert-butyl alcohol; 1: |Sharpless Dihydroxylation;

DOI:10.1016/j.tet.2013.10.082

Reference yield:

benzyl-(2S)-2-[(1S)-1,2-dihydroxyethyl]piperidine-1-carboxylate → (+)-dexoxadrol hydrochloride (631-06-1)

Guidance literature:

Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / ethanol / 6 h / 20 °C / 1900.13 Torr

2: toluene-4-sulfonic acid / isopropyl alcohol / 1 h / Reflux

3: hydrogenchloride / ethyl acetate

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; toluene-4-sulfonic acid; In ethanol; ethyl acetate; isopropyl alcohol;

DOI:10.1016/j.tet.2013.10.082

upstream raw materials:

(S)-benzyl-2-vinylpiperidine-1-carboxylate

dexoxadrol

dimethoxydiphenylmethane

(βS,2S)-β-hydroxypiperidin-2-ethanol

Refernces