1,2-Dibromo-1-ethoxyethane

Base Information

• Chemical Name: 1,2-Dibromo-1-ethoxyethane
• CAS No.: 2983-26-8
• Deprecated CAS: 105431-36-5
• Molecular Formula: C4H8Br2O
• Molecular Weight: 231.915
• European Community (EC) Number: 221-040-7
• DSSTox Substance ID: DTXSID10883927
• Nikkaji Number: J205.274A
• Mol file: 2983-26-8.mol

Synonyms:1,2-Dibromo-1-ethoxyethane;2983-26-8;Ethane, 1,2-dibromo-1-ethoxy-;1,2-dibromo-1-ethoxy-ethane;EINECS 221-040-7;105431-36-5;C4H8Br2O;1,2-dibromo-2-ethoxyethane;1,2-dibromoethyl ethyl ether;SCHEMBL2071027;DTXSID10883927;AKOS005266801;FT-0657545;A801239

Chemical Property of 1,2-Dibromo-1-ethoxyethane

Chemical Property:

• Vapor Pressure: 0.453mmHg at 25°C
• Refractive Index: 1.503
• Boiling Point: 200.7 °C at 760 mmHg
• Flash Point: 76.4 °C
• PSA: 9.23000
• Density: 1.816 g/cm³
• LogP: 2.13880
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 231.89214
• Heavy Atom Count: 7
• Complexity: 40.7

Purity/Quality:

98.00% ^*data from raw suppliers

1,2-DIBROMO-1-ETHOXYETHANE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(CBr)Br

Technology Process of 1,2-Dibromo-1-ethoxyethane

There total 5 articles about 1,2-Dibromo-1-ethoxyethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

ethyl vinyl ether (109-92-2,25104-37-4) → 1,2-dibromoethyl ethyl ether (2983-26-8)

Guidance literature:

With bromine; In dichloromethane; Ambient temperature;

DOI:10.1021/jo00369a004

Reference yield:

1-chloroethyl ethyl ether (7081-78-9) → 1,2-dibromoethyl ethyl ether (2983-26-8)

Guidance literature:

With bromine;

Reference yield:

ethanol (64-17-5) + acetaldehyde (75-07-0,9002-91-9) → 1,2-dibromoethyl ethyl ether (2983-26-8)

Guidance literature:

With bromine; at 0 ℃;

upstream raw materials:

1-chloroethyl ethyl ether

ethanol

acetaldehyde

ethyl vinyl ether

Downstream raw materials:

ethyl-(1-bromomethyl-3-phenyl-prop-2-ynyl)-ether

1-bromo-2,2-dimethoxyethane

bis-[4-(1,2-dibromo-ethyl)-phenyl]-ether

4-(1,2-dibromo-ethyl)-1,2-dimethoxy-benzene

Refernces

• 1、 Gornez, Ana M.,Casillas, Marta,Valverde, Serafin,Lopez, J. Cristobal. "Stereocontrolled entry to β-C-glycosides and bis-C,C-glycosides from C-glycals: preparation of a highly functionalized triene from D-mannose". . p. 2175 - 2184. Retrieved 2001.
• 2、 Ebrahim,Evans,Lehmann,Ziser. "Mixed-acetal glucopyranosides of 2-bromo- and 2-iodo-acetaldehyde by mild alkylation of lactol groups. Irreversible cross inhibition using a pair of glycosidases". . p. 189 - 196. Retrieved 1996.
• 3、 Tutwiler,Cook. "-". . p. 425. Retrieved 1959.
• 4、 Zhang, Jian-Jian,Yan, Chang-Song,Peng, Yu,Luo, Zhen-Biao,Xu, Xiao-Bo,Wang, Ya-Wen. "Total synthesis of (±)-sacidumlignans D and A through Ueno-Stork radical cyclization reaction". . p. 2498 - 2513. Retrieved 2013/06/26.
• 5、 Toumieux, Sylvestre,Beniazza, Redouane,Desvergnes, Valerie,Araoz, Romulo,Molgo, Jordi,Landais, Yannick. "Synthesis of the gymnodimine tetrahydrofuran core through a Ueno-Stork radical cyclization". supporting information; experimental part. p. 3726 - 3732. Retrieved 2011/06/27.